General Structure Information
| PDB ID | 2knc |
| HGNC Gene Label(s) | ITGB3 |
| Structure Name | platelet integrin alfaiib-beta3 transmembrane-cytoplasmic heterocomplex |
| Resolution | -1.0Å |
| Reference | AUTH J.YANG,Y.Q.MA,R.C.PAGE,S.MISRA,E.F.PLOW,J.QINTITL STRUCTURE OF AN INTEGRIN ALPHAIIB BETA3TITL 2 TRANSMEMBRANE-CYTOPLASMIC HETEROCOMPLEX PROVIDES INSIGHTTITL 3 INTO INTEGRIN ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 17729 2009REFN ISSN 0027-8424PMID 19805198DOI 10.1073/PNAS.0909589106 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 74 |
| Number Of SNVs | 21 |
| Number Of Permutations | 6716 |
| Optimal Distance Threshold | 31.0 |
| K Statistic | 0.552 |
| p-value | 0.166 |
ClinVar
| Number Of Residues | 74 |
| Number Of SNVs | 3 |
| Number Of Permutations | 383 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.333 |
| p-value | 0.928 |
Ripley’s K Analysis Plots
ExACClinVar
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 21 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.224 |
| p-value | 1.0 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
