4ACQ.B | A2M – ASTRID

4ACQ.B | A2M

General Structure Information

PDB ID	4acq
HGNC Gene Label(s)	A2M
Structure Name	alpha-2 macroglobulin
Resolution	4.3Å
Reference	AUTH A.MARRERO,S.DUQUERROY,S.TRAPANI,T.GOULAS,T.GUEVARA,AUTH 2 G.R.ANDERSEN,J.NAVAZA,L.SOTTRUP-JENSEN,F.X.GOMIS-RUTHTITL THE CRYSTAL STRUCTURE OF HUMAN ALPHA(2)-MACROGLOBULINTITL 2 REVEALS A UNIQUE MOLECULAR CAGE.REF ANGEW.CHEM.INT.ED.ENGL. V. 51 3340 2012REFN ISSN 1433-7851PMID 22290936DOI 10.1002/ANIE.201108015

Variant Set Distributions

ExAC Variants

Number Of Residues	1269
Number Of SNVs	286
Number Of Permutations	88624
Optimal Distance Threshold	7.0
K Statistic	0.005
p-value	0.748

COSMIC

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	286
Number Of COSMIC SNVs	17
Optimal Distance Threshold	11.0
K Statistic	0.012
p-value	0.698

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
12:9268360	rs368215969 COSM695445	P>L	B:29	(113.28, 129.07, 35.60)
12:9266129		V>F	B:33	(110.27, 136.02, 48.04)
12:9266120	COSM3466425	P>S	B:36	(108.04, 138.39, 57.75)
12:9266117		S>A	B:37	(103.75, 137.18, 58.61)
12:9266111		L>F	B:39	(105.45, 143.17, 59.42)
12:9266105		T>A	B:41	(105.29, 149.72, 62.17)
12:9266056	rs200420993	T>I	B:57	(119.10, 140.14, 34.47)
12:9266044		S>N	B:61	(108.81, 144.52, 42.84)
12:9266041		A>V	B:62	(107.34, 144.88, 46.77)
12:9266035		L>S	B:64	(102.38, 147.03, 51.57)
12:9266015	rs199673531	R>W	B:71	(98.68, 153.08, 53.45)
12:9265990		A>V	B:79	(118.89, 139.92, 42.73)
12:9265986		E>D	B:80	(122.32, 138.41, 43.28)
12:9265976		L>V	B:84	(120.46, 134.63, 49.64)
12:9265967		V>L	B:87	(115.76, 143.98, 51.34)
12:9265958	rs375536103 COSM1181118	A>T	B:90	(110.19, 150.35, 58.16)
12:9265125		K>M	B:93	(100.91, 152.20, 60.06)
12:9265122		S>F	B:94	(97.70, 153.95, 60.59)
12:9265106		E>D	B:99	(96.41, 147.72, 59.24)
12:9265105		V>I	B:100	(95.31, 143.53, 57.57)
12:9265098		F>Y	B:102	(96.37, 143.17, 50.01)
12:9265099	rs114851022	F>L	B:102	(96.37, 143.17, 50.01)
12:9265089		V>A	B:105	(105.60, 140.17, 44.78)
12:9265090		V>L	B:105	(105.60, 140.17, 44.78)
12:9265086		Q>R	B:106	(106.04, 142.61, 39.85)
12:9265078		G>R	B:109	(110.86, 141.14, 32.73)
12:9265053		R>L	B:117	(97.30, 139.19, 45.90)
12:9265054	COSM3417261	R>W	B:117	(97.30, 139.19, 45.90)
12:9265047		T>K	B:119	(97.04, 138.43, 53.95)
12:9265027		D>N	B:126	(105.40, 149.15, 72.94)
12:9265022	rs369090397	S>R	B:127	(108.56, 149.08, 74.88)
12:9265011		V>A	B:131	(110.20, 150.02, 87.44)
12:9264991		Y>H	B:138	(110.10, 152.27, 100.95)
12:9264798	rs201769751 COSM944425	R>H	B:147	(116.64, 153.45, 88.78)
12:9264799	COSM1177109	R>C	B:147	(116.64, 153.45, 88.78)
12:9264787		M>V	B:151	(114.49, 148.34, 76.30)
12:9264771		H>L	B:156	(119.35, 148.80, 71.67)
12:9264761	rs374407122	N>K	B:159	(115.52, 158.35, 74.09)
12:9264759	rs200572417	E>V	B:160	(109.69, 156.07, 75.11)
12:9262631		D>N	B:169	(97.10, 154.95, 97.28)
12:9262623		K>N	B:171	(92.79, 153.09, 99.90)
12:9262625		K>Q	B:171	(92.79, 153.09, 99.90)
12:9262622		G>R	B:172	(93.72, 154.43, 94.81)
12:9262616	COSM1364855	R>C	B:174	(96.62, 159.24, 90.24)
12:9262610	COSM944422	A>T	B:176	(102.38, 160.95, 92.23)
12:9262607		Q>K	B:177	(101.37, 163.16, 88.29)
12:9262602		W>C	B:178	(106.50, 161.89, 88.21)
12:9262595		F>L	B:181	(108.94, 161.98, 80.60)
12:9262592	rs377549857	Q>K	B:182	(112.68, 162.33, 76.27)
12:9262586	COSM3466414	E>Q	B:184	(117.97, 161.42, 78.74)
12:9262562		F>L	B:192	(107.50, 159.81, 96.32)
12:9262558		P>L	B:193	(108.08, 162.37, 98.96)
12:9262559	COSM1188433	P>S	B:193	(108.08, 162.37, 98.96)
12:9262534		G>D	B:201	(100.72, 149.09, 102.36)
12:9262519		V>A	B:206	(101.72, 153.22, 87.16)
12:9262520		V>M	B:206	(101.72, 153.22, 87.16)
12:9262517		V>I	B:207	(104.46, 153.55, 83.62)
12:9262510		K>R	B:209	(102.83, 154.18, 77.61)
12:9262505		S>T	B:211	(99.85, 152.71, 73.84)
12:9262499		G>R	B:213	(100.69, 150.38, 78.63)
12:9262496		R>G	B:214	(98.06, 151.64, 82.92)
12:9262484		P>T	B:218	(105.08, 146.81, 93.49)
12:9262475	rs578188069	V>M	B:221	(104.56, 151.29, 103.29)
12:9261989	COSM1364853	F>S	B:229	(118.39, 137.03, 112.80)
12:9261981		Q>K	B:232	(119.50, 129.78, 106.57)
12:9261972		V>L	B:235	(113.40, 121.46, 102.93)
12:9261949	rs372695298	L>F	B:242	(105.95, 106.11, 100.23)
12:9261942		E>K	B:245	(113.69, 109.64, 104.94)
12:9261937		M>I	B:246	(112.06, 114.95, 105.85)
12:9261927		V>M	B:250	(117.38, 125.69, 111.15)
12:9260224	rs372036246	P>S	B:259	(127.27, 132.09, 113.89)
12:9260217	rs182493380	P>L	B:261	(123.40, 131.52, 119.14)
12:9260212		H>Y	B:263	(115.14, 127.62, 121.94)
12:9260181		S>N	B:273	(92.29, 117.60, 99.27)
12:9260170	rs140258425	D>N	B:277	(88.87, 125.51, 99.78)
12:9260164		H>Y	B:279	(86.04, 129.44, 103.81)
12:9260161		G>S	B:280	(84.38, 126.72, 108.14)
12:9260146		A>T	B:285	(96.02, 120.45, 109.80)
12:9260128	rs374513475	S>G	B:291	(112.32, 121.77, 120.47)
12:9260121	rs370213648	Q>R	B:293	(119.48, 125.45, 121.87)
12:9259194		S>T	B:296	(128.60, 127.87, 117.84)
12:9259191		H>R	B:297	(129.44, 125.82, 114.19)
12:9259185		C>Y	B:299	(122.35, 124.27, 113.57)
12:9259160		K>N	B:307	(104.49, 108.40, 106.91)
12:9259159		V>I	B:308	(102.71, 110.44, 109.35)
12:9259127		M>I	B:318	(104.73, 119.67, 103.16)
12:9259116		T>N	B:322	(110.60, 128.21, 111.76)
12:9259105		I>V	B:326	(118.44, 135.46, 120.45)
12:9259099		E>Q	B:328	(121.66, 137.33, 124.47)
12:9258921	rs200241721	Q>K	B:339	(106.24, 127.30, 102.91)
12:9258895		I>M	B:347	(107.25, 107.69, 90.93)
12:9258893		T>S	B:348	(109.66, 106.53, 87.55)
12:9258890		K>R	B:349	(108.60, 110.73, 83.70)
12:9258879	rs182431409	V>L	B:353	(116.16, 114.06, 74.25)
12:9258870		D>N	B:356	(114.14, 113.14, 64.06)
12:9258863	rs112506934	H>R	B:358	(112.19, 116.21, 60.93)
12:9258857	rs2229298	R>Q	B:360	(113.00, 112.62, 55.79)
12:9258852		G>R	B:362	(114.97, 105.76, 54.07)
12:9258839		F>S	B:366	(118.23, 110.01, 66.04)
12:9258840		F>L	B:366	(118.23, 110.01, 66.04)
12:9258834	rs200272487	Q>E	B:368	(118.18, 110.17, 72.68)
12:9256992	rs377153333	R>H	B:370	(117.87, 111.04, 80.03)
12:9256993	rs371980049	R>C	B:370	(117.87, 111.04, 80.03)
12:9256972	rs200364039	V>I	B:377	(117.78, 111.09, 89.92)
12:9256958		N>K	B:381	(122.12, 99.95, 84.97)
12:9256923		Y>C	B:393	(112.65, 99.23, 67.33)
12:9256902		D>G	B:400	(124.03, 105.20, 80.48)
12:9256899	rs367610653	E>A	B:401	(125.79, 105.78, 84.90)
12:9256896	rs375282521	H>R	B:402	(124.54, 109.78, 82.36)
12:9256876		I>V	B:409	(113.59, 103.36, 63.86)
12:9256872		N>T	B:410	(112.83, 100.43, 59.56)
12:9256867		T>A	B:412	(109.22, 100.14, 55.58)
12:9256851		T>N	B:417	(105.58, 107.01, 63.13)
12:9256852		T>A	B:417	(105.58, 107.01, 63.13)
12:9256849		S>P	B:418	(103.82, 105.43, 66.65)
12:9256846		L>V	B:419	(107.41, 106.38, 68.98)
12:9256842		T>N	B:420	(105.92, 104.37, 73.17)
12:9254266		N>S	B:424	(106.28, 100.36, 85.98)
12:9254257		D>V	B:427	(97.39, 98.97, 87.50)
12:9254254	rs61730080	R>H	B:428	(101.04, 98.15, 91.93)
12:9254255		R>C	B:428	(101.04, 98.15, 91.93)
12:9254228		V>M	B:437	(98.20, 108.47, 86.09)
12:9254209	rs369016153	E>G	B:443	(105.51, 107.72, 79.73)
12:9254204	rs372489202	H>Y	B:445	(103.76, 108.90, 74.39)
12:9254183		F>L	B:452	(105.72, 116.22, 49.59)
12:9254179	COSM1606750	S>F	B:453	(108.05, 112.74, 48.39)
12:9254172		S>R	B:455	(112.20, 113.72, 43.72)
12:9254164		F>S	B:458	(114.43, 113.35, 50.90)
12:9254153	rs61730079	E>K	B:462	(121.11, 116.45, 63.60)
12:9254136		E>D	B:467	(120.24, 125.80, 76.77)
12:9254135	rs202178042	L>I	B:468	(122.52, 126.44, 72.27)
12:9254128		C>Y	B:470	(125.80, 132.79, 74.50)
12:9254094		I>M	B:481	(119.10, 111.82, 49.09)
12:9254053		F>S	B:495	(121.98, 123.42, 49.74)
12:9254054	rs200091633	F>V	B:495	(121.98, 123.42, 49.74)
12:9254050		Y>C	B:496	(120.34, 128.77, 49.45)
12:9253793		K>R	B:502	(113.53, 138.83, 68.71)
12:9253764		G>R	B:512	(127.80, 124.41, 48.57)
12:9252102		I>V	B:526	(126.75, 124.86, 58.76)
12:9252098	rs200185734	S>L	B:527	(128.60, 127.28, 61.17)
12:9252078		I>V	B:534	(119.67, 134.19, 68.44)
12:9252071		P>R	B:536	(114.65, 132.44, 73.21)
12:9252066	rs201235306	A>T	B:538	(116.33, 129.11, 67.17)
12:9252062		R>Q	B:539	(112.01, 128.33, 64.87)
12:9252063		R>W	B:539	(112.01, 128.33, 64.87)
12:9252050		Y>C	B:543	(115.78, 126.99, 50.21)
12:9252023	rs200177356	I>T	B:552	(114.10, 119.63, 49.18)
12:9252000	rs191018657	V>I	B:560	(119.00, 130.12, 72.93)
12:9251979	rs376425831	K>E	B:567	(128.86, 140.60, 79.13)
12:9251344		L>F	B:570	(129.90, 144.74, 90.89)
12:9251342		S>N	B:571	(133.63, 144.83, 93.20)
12:9251319	rs374437029	P>A	B:579	(133.85, 153.52, 109.97)
12:9251316		A>T	B:580	(135.89, 152.61, 106.51)
12:9251307		A>T	B:583	(135.57, 151.36, 99.33)
12:9251297	rs190555000	R>Q	B:586	(136.33, 149.01, 90.97)
12:9251288	rs377690298	A>V	B:589	(131.51, 147.35, 80.92)
12:9251283	COSM3667250	P>S	B:591	(132.79, 150.96, 76.10)
12:9251274	rs373288303	V>I	B:594	(124.83, 154.36, 81.49)
12:9251268	rs368979443	A>T	B:596	(122.87, 151.57, 87.62)
12:9251234		M>T	B:607	(111.95, 142.74, 105.51)
12:9251229		P>A	B:609	(112.28, 140.32, 98.55)
12:9251213	rs373637929 COSM3720657	S>L	B:614	(115.65, 143.60, 87.09)
12:9251204	rs531579697 COSM1562418	S>L	B:617	(112.51, 140.44, 84.41)
12:9248289		N>S	B:620	(109.80, 137.65, 80.56)
12:9248265		T>I	B:628	(104.55, 129.69, 65.70)
12:9248263		G>S	B:629	(102.66, 130.65, 62.54)
12:9248232		N>S	B:639	(93.20, 129.58, 51.04)
12:9248233	rs226405	N>D	B:639	(93.20, 129.58, 51.04)
12:9248214	rs200062192	R>H	B:645	(88.53, 118.41, 43.12)
12:9248211		H>R	B:646	(89.66, 116.25, 40.39)
12:9248209		N>D	B:647	(88.77, 113.46, 42.28)
12:9248197		N>D	B:651	(91.04, 102.51, 37.99)
12:9248181		T>I	B:656	(89.31, 104.70, 44.85)
12:9248157		K>R	B:664	(104.67, 116.97, 55.31)
12:9248151		M>T	B:666	(108.48, 123.14, 52.22)
12:9248152		M>V	B:666	(108.48, 123.14, 52.22)
12:9247673		G>D	B:674	(106.92, 132.77, 59.91)
12:9247643	rs369822629	R>H	B:684	(102.58, 122.76, 48.23)
12:9247637		P>L	B:686	(98.53, 119.03, 46.29)
12:9246109		V>E	B:731	(133.54, 156.57, 118.34)
12:9246110	rs367601457	V>I	B:731	(133.54, 156.57, 118.34)
12:9246077	rs545926870	D>N	B:742	(124.88, 156.69, 91.79)
12:9246065		V>L	B:746	(132.50, 152.85, 81.48)
12:9244012		A>T	B:752	(135.28, 153.63, 89.95)
12:9243997		T>A	B:757	(131.71, 152.46, 104.90)
12:9243980	rs369403894	I>M	B:762	(124.57, 145.95, 110.96)
12:9243974	rs375590271	E>D	B:764	(126.51, 141.38, 104.62)
12:9243922		S>P	B:782	(126.41, 140.07, 89.76)
12:9243888		F>S	B:793	(129.18, 144.92, 117.57)
12:9243876		T>I	B:797	(116.72, 145.66, 121.43)
12:9243867		Y>C	B:800	(108.49, 152.69, 114.40)
12:9243855	rs117138141	R>H	B:804	(103.90, 161.30, 126.09)
12:9243828		T>M	B:813	(123.91, 143.42, 123.02)
12:9243820		N>D	B:816	(133.66, 139.73, 122.12)
12:9243804		C>Y	B:821	(139.19, 138.04, 127.60)
12:9243799	rs372194305	R>W	B:823	(134.96, 142.32, 134.07)
12:9243078		V>F	B:824	(132.01, 145.24, 129.78)
12:9243072		V>M	B:826	(127.39, 148.92, 130.16)
12:9243060		A>T	B:830	(120.68, 160.83, 130.39)
12:9243042		A>P	B:836	(116.29, 154.84, 133.13)
12:9243032		V>A	B:839	(117.54, 145.39, 135.47)
12:9243018		A>T	B:844	(129.64, 145.64, 138.09)
12:9243008		C>F	B:847	(132.67, 138.00, 133.15)
12:9242994	COSM1181113	G>R	B:852	(129.83, 136.64, 123.47)
12:9242991		R>W	B:853	(125.64, 137.54, 122.92)
12:9242613		V>E	B:868	(113.96, 160.32, 121.23)
12:9242602		V>M	B:872	(124.83, 153.38, 124.73)
12:9242574		E>G	B:881	(144.17, 142.19, 138.52)
12:9242569		C>R	B:883	(137.36, 136.55, 136.87)
12:9242536		G>R	B:894	(138.61, 149.47, 119.88)
12:9242523		T>R	B:898	(129.52, 155.25, 121.06)
12:9242511		P>L	B:902	(116.67, 157.21, 116.94)
12:9241847		P>T	B:907	(100.96, 160.55, 121.58)
12:9241840		G>A	B:909	(95.80, 157.91, 124.08)
12:9241816		N>S	B:917	(83.40, 165.37, 103.66)
12:9241813		S>C	B:918	(82.93, 168.99, 100.92)
12:9232743	rs200673507	K>I	B:934	(85.08, 172.03, 118.70)
12:9232732	rs201451491	N>D	B:938	(89.41, 165.50, 127.11)
12:9232723		E>K	B:941	(99.19, 168.78, 125.28)
12:9232699		S>P	B:949	(92.07, 166.63, 100.55)
12:9232405	rs200161546	I>T	B:954	(88.22, 161.28, 86.84)
12:9232406	rs368831189	I>V	B:954	(88.22, 161.28, 86.84)
12:9232391		M>V	B:959	(87.13, 154.33, 83.62)
12:9232386		Q>H	B:960	(90.61, 152.03, 83.91)
12:9232360	rs187174798	P>L	B:969	(75.06, 139.02, 71.62)
12:9232349		G>R	B:973	(65.80, 135.61, 76.45)
12:9232336		M>T	B:977	(68.76, 141.51, 77.95)
12:9232325	rs201667231	A>S	B:981	(71.84, 146.01, 78.80)
12:9232312	rs371544008	Y>C	B:985	(73.06, 151.26, 80.93)
12:9232310		V>I	B:986	(79.32, 150.80, 79.05)
12:9232304		D>N	B:988	(75.43, 156.09, 78.96)
12:9232288	rs200926793	T>I	B:993	(83.55, 160.02, 81.61)
12:9232276		T>I	B:997	(87.77, 155.17, 71.77)
12:9232267		I>T	B:1000	(86.00, 150.63, 71.56)
12:9232268	rs669	I>V	B:1000	(86.00, 150.63, 71.56)
12:9232262		S>P	B:1002	(82.37, 151.05, 66.37)
12:9232258		K>T	B:1003	(84.70, 147.07, 68.01)
12:9232252	rs558034541	I>T	B:1005	(77.24, 150.34, 67.77)
12:9231907		Y>H	B:1018	(63.31, 135.71, 72.29)
12:9231891		G>D	B:1023	(54.51, 142.71, 73.17)
12:9231876		F>C	B:1028	(61.67, 129.70, 76.01)
12:9231867	rs202210880 COSM3466397	R>Q	B:1031	(59.37, 130.59, 69.96)
12:9231864		Y>C	B:1032	(58.49, 126.96, 70.18)
12:9231854		N>K	B:1035	(52.26, 130.61, 75.55)
12:9231840		W>L	B:1040	(62.04, 142.25, 85.30)
12:9230422		Q>K	B:1051	(68.61, 154.16, 77.78)
12:9230415		R>Q	B:1053	(65.02, 155.96, 72.61)
12:9230412	rs376352242	A>D	B:1054	(70.38, 157.35, 71.98)
12:9230400	rs371433665	I>T	B:1058	(64.77, 151.52, 68.57)
12:9230392		A>T	B:1061	(56.52, 150.13, 67.94)
12:9230388		H>L	B:1062	(59.25, 147.55, 69.04)
12:9230307		N>S	B:1089	(65.38, 134.84, 89.59)
12:9230012		G>E	B:1094	(63.29, 142.37, 92.61)
12:9230013	rs149872679	G>R	B:1094	(63.29, 142.37, 92.61)
12:9229986	rs113563450	A>T	B:1103	(58.67, 150.07, 91.44)
12:9229971		A>T	B:1108	(60.58, 152.31, 83.54)
12:9229967		L>R	B:1109	(56.62, 153.91, 82.56)
12:9229956		P>A	B:1113	(60.07, 159.96, 77.83)
12:9229949		T>R	B:1115	(54.65, 162.00, 82.42)
12:9229519	COSM3793031	R>H	B:1122	(45.74, 158.53, 86.79)
12:9229520		R>C	B:1122	(45.74, 158.53, 86.79)
12:9229508		F>L	B:1126	(46.56, 156.03, 93.29)
12:9229492		A>V	B:1131	(53.58, 152.15, 100.14)
12:9229467	COSM944405	D>E	B:1139	(60.56, 147.07, 110.71)
12:9229453		V>E	B:1144	(65.64, 148.87, 103.05)
12:9229447		T>N	B:1146	(61.45, 148.77, 98.56)
12:9229427		A>T	B:1153	(60.08, 157.47, 91.61)
12:9229411		G>V	B:1158	(58.28, 165.36, 91.19)
12:9229407		N>K	B:1159	(56.05, 164.24, 94.62)
12:9229409		N>D	B:1159	(56.05, 164.24, 94.62)
12:9229399	rs61730087	K>R	B:1162	(55.52, 162.44, 99.44)
12:9229390	rs200419261	E>G	B:1165	(58.37, 162.75, 103.63)
12:9229385		L>F	B:1167	(65.53, 160.54, 100.84)
12:9229381		K>T	B:1168	(64.98, 163.28, 106.03)
12:9229363		A>G	B:1174	(71.97, 154.38, 106.64)
12:9229364		A>T	B:1174	(71.97, 154.38, 106.64)
12:9229361		V>M	B:1175	(75.58, 152.46, 106.74)
12:9227358		R>H	B:1185	(67.55, 143.64, 102.48)
12:9227337		P>L	B:1192	(65.78, 131.28, 104.90)
12:9227335		V>L	B:1193	(62.84, 127.62, 105.05)
12:9227320		E>K	B:1198	(64.83, 133.90, 96.52)
12:9227311	COSM1283135	A>T	B:1201	(68.45, 141.03, 98.13)
12:9227259		T>M	B:1218	(66.51, 163.13, 89.89)
12:9227256		A>D	B:1219	(65.89, 167.30, 90.88)
12:9227241		T>N	B:1224	(70.98, 171.27, 95.36)
12:9227238		S>L	B:1225	(75.21, 171.49, 96.67)
12:9227233		D>Y	B:1227	(71.20, 167.26, 96.81)
12:9227223	rs370256138	S>F	B:1230	(74.95, 163.43, 99.78)
12:9227218	rs375665719	T>A	B:1232	(79.58, 162.73, 96.46)
12:9227212		I>V	B:1234	(76.51, 157.49, 97.81)
12:9227209		V>M	B:1235	(80.06, 157.55, 94.47)
12:9227196	rs61730090	T>M	B:1239	(84.09, 153.29, 92.65)
12:9227166		S>F	B:1249	(77.91, 142.03, 90.83)
12:9225448	rs376118057	H>P	B:1259	(71.51, 155.26, 84.73)
12:9225428		A>T	B:1266	(76.78, 165.24, 84.39)
12:9225419		F>L	B:1269	(83.14, 165.63, 84.45)
12:9225416		T>P	B:1270	(83.10, 170.83, 82.61)
12:9225403		K>T	B:1274	(90.29, 174.54, 81.26)
12:9225395	rs372114265	Q>K	B:1277	(91.41, 178.54, 91.86)
12:9225389		T>A	B:1279	(91.65, 179.47, 98.07)
12:9225371		T>S	B:1285	(98.45, 183.83, 108.97)
12:9225346		D>G	B:1293	(93.61, 171.14, 85.25)
12:9225342		N>K	B:1294	(92.15, 168.97, 82.20)
12:9225334	COSM1181115	R>H	B:1297	(89.25, 166.81, 87.71)
12:9225335	rs376258518	R>C	B:1297	(89.25, 166.81, 87.71)
12:9225290	rs140896462	Y>H	B:1312	(90.84, 177.04, 109.36)
12:9225078		S>Y	B:1327	(91.04, 164.89, 108.55)
12:9225079		S>T	B:1327	(91.04, 164.89, 108.55)
12:9225064		I>V	B:1332	(90.83, 161.59, 124.22)
12:9225054		E>G	B:1335	(85.42, 159.17, 130.39)

4ACQ.B | A2M.

4ACQ.B | A2M

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants