3KCI.A | HERC2

General Structure Information

PDB ID	3kci
HGNC Gene Label(s)	HERC2
Structure Name	the third rld domain of herc2
Resolution	1.8Å
Reference	AUTH J.R.WALKER,L.QIU,A.VESTERBERG,J.WEIGELT,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL STRUCTURE OF THE THIRD RLD DOMAIN OF HERC2REF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	366
Number Of SNVs	62
Number Of Permutations	6060
Optimal Distance Threshold	14.0
K Statistic	0.121
p-value	0.17

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
15:28386732		I>T	A:3954	(10.35, 26.05, 30.78)
15:28386682		A>T	A:3971	(1.27, 26.22, 15.19)
15:28386670	rs376550266	V>L	A:3975	(0.48, 32.70, 25.04)
15:28386666		P>R	A:3976	(3.31, 32.53, 27.46)
15:28386667		P>S	A:3976	(3.31, 32.53, 27.46)
15:28386643		T>A	A:3984	(11.87, 17.27, 32.33)
15:28386630		V>A	A:3988	(21.98, 24.66, 31.80)
15:28386631	rs374245104	V>M	A:3988	(21.98, 24.66, 31.80)
15:28386601		F>L	A:3998	(19.25, 22.94, 19.87)
15:28386595		V>M	A:4000	(22.34, 21.90, 27.65)
15:28386591	rs372578918	T>M	A:4001	(21.88, 18.81, 30.48)
15:28386589		A>T	A:4002	(23.73, 19.37, 34.06)
15:28386585		D>V	A:4003	(24.32, 15.55, 32.70)
15:28380817		A>T	A:4013	(16.44, 19.83, 7.55)
15:28380799		I>V	A:4019	(19.10, 13.30, 16.04)
15:28380783	COSM960133	S>L	A:4024	(11.27, 16.27, 12.11)
15:28380772		P>S	A:4028	(12.78, 16.68, 23.60)
15:28380769	rs560156561 COSM4053819	T>A	A:4029	(15.58, 14.13, 20.81)
15:28380765	rs372169108	L>S	A:4030	(19.52, 12.11, 23.26)
15:28380754		I>V	A:4034	(27.65, 13.54, 21.94)
15:28380739		I>V	A:4039	(28.35, 19.45, 26.07)
15:28380724		V>L	A:4044	(22.62, 28.32, 17.09)
15:28380714	rs368139355	G>E	A:4047	(19.04, 31.34, 11.28)
15:28380683		E>D	A:4057	(36.98, 17.94, 27.23)
15:28377974	rs201061030	P>L	A:4078	(27.18, 17.12, 5.05)
15:28377966		R>C	A:4081	(24.76, 11.70, 13.76)
15:28377935	rs200047478	I>T	A:4091	(43.46, 24.64, 21.11)
15:28377881		A>V	A:4109	(44.09, 33.34, 25.48)
15:28377879		G>R	A:4110	(41.62, 35.27, 23.63)
15:28377869	rs377021578	Y>C	A:4113	(40.57, 30.57, 16.08)
15:28377842		R>Q	A:4122	(30.73, 36.95, 6.97)
15:28377828	rs374709094	D>N	A:4127	(40.06, 38.14, 2.85)
15:28377818		D>G	A:4130	(35.57, 30.76, 1.85)
15:28377400	rs200811930	A>V	A:4139	(43.61, 41.75, 14.25)
15:28377391	COSM3420219	G>V	A:4142	(46.13, 41.60, 22.15)
15:28377385		R>H	A:4144	(41.64, 37.94, 26.83)
15:28377374		I>V	A:4148	(31.52, 36.11, 19.85)
15:28377371		A>T	A:4149	(28.53, 37.43, 17.66)
15:28377315		W>C	A:4167	(36.89, 45.35, 18.30)
15:28377278		G>R	A:4180	(27.78, 54.57, 9.88)
15:28377256		V>A	A:4187	(39.18, 44.04, 9.69)
15:28377250	rs376611895	M>T	A:4189	(36.84, 48.22, 12.74)
15:28377251		M>V	A:4189	(36.84, 48.22, 12.74)
15:28377248	rs146646815	K>E	A:4190	(37.73, 49.94, 17.90)
15:28375731		L>V	A:4194	(30.00, 51.18, 22.69)
15:28375718		G>E	A:4198	(30.07, 48.17, 29.90)
15:28375707	rs143291915	V>M	A:4202	(27.31, 41.06, 21.91)
15:28375677		L>V	A:4212	(23.66, 44.22, 27.79)
15:28375659	rs545465333	V>I	A:4218	(19.62, 47.82, 25.54)
15:28375414	rs138063419	S>T	A:4233	(10.75, 53.43, 14.07)
15:28375407		D>V	A:4235	(13.95, 54.58, 10.71)
15:28375398		R>Q	A:4238	(22.93, 53.67, 9.57)
15:28375394		R>S	A:4239	(26.66, 55.72, 14.68)
15:28375354	rs145535698	A>T	A:4253	(19.01, 39.24, 29.72)
15:28375323	rs571199554	C>S	A:4263	(14.32, 41.04, 27.93)
15:28375320		C>Y	A:4264	(15.19, 39.93, 31.70)
15:28375317	rs551124716	T>I	A:4265	(14.58, 42.55, 34.69)
15:28375310	rs373175587	D>E	A:4267	(13.09, 42.65, 39.81)
15:28370295		D>N	A:4283	(0.53, 39.64, 22.75)
15:28370291		G>E	A:4284	(-2.05, 36.95, 21.66)
15:28370282		N>S	A:4287	(-0.21, 42.34, 16.16)
15:28370264	rs545280792	R>Q	A:4293	(4.37, 45.94, 24.81)
15:28370265	COSM700283	R>W	A:4293	(4.37, 45.94, 24.81)
15:28370244		G>S	A:4300	(5.49, 36.62, 38.83)
15:28370228	rs139596817	R>H	A:4305	(18.11, 32.35, 32.94)
15:28370229	rs370346800	R>C	A:4305	(18.11, 32.35, 32.94)
15:28370199	COSM960117	A>T	A:4315	(11.11, 31.86, 29.64)