General Structure Information
| PDB ID | 3p23 |
| HGNC Gene Label(s) | ERN1 |
| Structure Name | crystal structure of the human kinase and rnase domains in complex with adp |
| Resolution | 2.7Å |
| Reference | AUTH M.M.ALI,T.BAGRATUNI,E.L.DAVENPORT,P.R.NOWAK,AUTH 2 M.C.SILVA-SANTISTEBAN,A.HARDCASTLE,C.MCANDREWS,M.G.ROWLANDS,AUTH 3 G.J.MORGAN,W.AHERNE,I.COLLINS,F.E.DAVIES,L.H.PEARLTITL STRUCTURE OF THE IRE1 AUTOPHOSPHORYLATION COMPLEX ANDTITL 2 IMPLICATIONS FOR THE UNFOLDED PROTEIN RESPONSE.REF EMBO J. V. 30 894 2011REFN ISSN 0261-4189PMID 21317875DOI 10.1038/EMBOJ.2011.18 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 386 |
| Number Of SNVs | 87 |
| Number Of Permutations | 60302 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.367 |
| p-value | 0.235 |
COSMIC
| Number Of Residues | 386 |
| Number Of SNVs | 6 |
| Number Of Permutations | 5266 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.067 |
| p-value | 0.519 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 87 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.054 |
| p-value | 0.526 |