General Structure Information
| PDB ID | 4j5w |
| HGNC Gene Label(s) | NR1I2 |
| Structure Name | crystal structure of the apo-pxr/rxralpha lbd heterotetramer complex |
| Resolution | 2.8Å |
| Reference | AUTH B.D.WALLACE,L.BETTS,G.TALMAGE,R.M.POLLET,N.S.HOLMAN,AUTH 2 M.R.REDINBOTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE HUMAN NUCLEARTITL 2 XENOBIOTIC RECEPTOR PXR IN COMPLEX WITH RXRALPHA.REF J.MOL.BIOL. V. 425 2561 2013REFN ISSN 0022-2836PMID 23602807DOI 10.1016/J.JMB.2013.04.012 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 275 |
| Number Of SNVs | 84 |
| Number Of Permutations | 40859 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.101 |
| p-value | 0.089 |
COSMIC
| Number Of Residues | 275 |
| Number Of SNVs | 4 |
| Number Of Permutations | 303 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.167 |
| p-value | 0.343 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 84 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.297 |
| p-value | 0.122 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
