General Structure Information
| PDB ID | 4aot |
| HGNC Gene Label(s) | STK10 |
| Structure Name | crystal structure of human serine threonine kinase-10 (lok) bound to gw830263a |
| Resolution | 2.33Å |
| Reference | AUTH J.M.ELKINS,E.SALAH,M.SZKLARZ,P.CANNING,F.VON DELFT,W.YUE,AUTH 2 Y.LIU,C.BOUNTRA,C.ARROWSMITH,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN SERINE THREONINE KINASE-10 (LOK)TITL 2 BOUND TO GW830263AREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 276 |
| Number Of SNVs | 74 |
| Number Of Permutations | 36380 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.221 |
| p-value | 0.42 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 5:171614979 | Y>S | A:23 | (15.93, -21.62, -1.87) | |
| 5:171614974 | H>Y | A:25 | (9.34, -20.37, 1.12) | |
| 5:171614965 | R>C | A:28 | (13.43, -28.41, -5.31) | |
| 5:171614960 | rs566181069 | D>E | A:29 | (10.25, -33.70, -6.15) |
| 5:171614954 | rs546732736 | D>E | A:31 | (3.40, -33.51, -9.06) |
| 5:171614950 | N>D | A:33 | (-0.71, -32.00, -10.51) | |
| 5:171614947 | E>K | A:34 | (0.15, -35.50, -6.40) | |
| 5:171614944 | rs144580417 | V>M | A:35 | (-1.72, -31.12, -3.97) |
| 5:171614933 | I>M | A:38 | (-5.99, -27.25, -12.77) | |
| 5:171614929 | G>S | A:40 | (-8.48, -23.03, -14.64) | |
| 5:171614924 | E>D | A:41 | (-6.73, -20.57, -18.04) | |
| 5:171614892 | rs369187536 | K>R | A:52 | (-8.94, -21.41, -10.28) |
| 5:171583788 | K>R | A:54 | (-10.05, -27.10, -5.58) | |
| 5:171583789 | K>E | A:54 | (-10.05, -27.10, -5.58) | |
| 5:171583780 | E>K | A:57 | (-6.62, -32.17, 2.06) | |
| 5:171583776 | rs371185883 | T>M | A:58 | (-8.94, -28.36, 1.70) |
| 5:171583774 | G>C | A:59 | (-10.75, -26.52, -1.22) | |
| 5:171583749 | I>T | A:67 | (7.52, -20.52, -15.01) | |
| 5:171583714 | I>V | A:79 | (13.63, -18.52, -6.10) | |
| 5:171583703 | rs575307141 | I>M | A:82 | (9.34, -16.58, -4.34) |
| 5:171583698 | I>S | A:84 | (11.16, -11.03, -1.32) | |
| 5:171583684 | D>N | A:89 | (2.55, -10.60, 6.71) | |
| 5:171583672 | rs142625010 | I>V | A:93 | (0.54, -7.85, -0.00) |
| 5:171583669 | V>M | A:94 | (-0.38, -11.26, -2.58) | |
| 5:171583647 | Y>C | A:101 | (11.78, -26.74, -10.22) | |
| 5:171583644 | rs377315172 | H>R | A:102 | (7.83, -31.15, -10.94) |
| 5:171583642 | rs374056362 COSM208050 |
D>N | A:103 | (9.40, -30.67, -14.45) |
| 5:171554418 | rs200140264 | I>T | A:110 | (-0.94, -16.91, -4.68) |
| 5:171554395 | rs149323437 | V>M | A:118 | (-9.02, -3.17, -11.21) |
| 5:171554389 | rs561950892 | A>T | A:120 | (-10.66, -6.36, -15.79) |
| 5:171554379 | L>P | A:123 | (-11.99, -3.65, -19.82) | |
| 5:171544625 | R>K | A:127 | (-17.71, 1.62, -15.19) | |
| 5:171544611 | P>A | A:132 | (-14.85, 7.01, -4.11) | |
| 5:171544590 | R>C | A:139 | (-5.20, 4.46, 3.04) | |
| 5:171544575 | A>T | A:144 | (1.59, -1.67, 0.86) | |
| 5:171544572 | L>F | A:145 | (3.97, 0.82, -1.21) | |
| 5:171544549 | rs370942717 | R>S | A:152 | (15.84, -2.76, 2.80) |
| 5:171544524 | G>S | A:161 | (-3.05, -5.39, -12.78) | |
| 5:171544518 | V>M | A:163 | (-5.00, -4.20, -8.12) | |
| 5:171544510 | rs142301756 | M>I | A:165 | (-10.25, -7.18, -5.54) |
| 5:171544508 | T>N | A:166 | (-11.27, -9.42, -2.09) | |
| 5:171544503 | E>K | A:168 | (-13.93, -9.36, 1.63) | |
| 5:171544494 | I>V | A:171 | (-6.33, -4.37, -2.23) | |
| 5:171534797 | rs372811283 | G>S | A:194 | (4.97, -4.11, -22.82) |
| 5:171534790 | rs201303206 | P>L | A:196 | (6.58, 1.33, -20.63) |
| 5:171533799 | rs372525754 | M>L | A:205 | (17.26, 8.69, -18.35) |
| 5:171533759 | A>V | A:218 | (9.57, 4.91, -8.51) | |
| 5:171533752 | I>M | A:220 | (5.36, 7.04, -5.53) | |
| 5:171533754 | I>F | A:220 | (5.36, 7.04, -5.53) | |
| 5:171533751 | W>R | A:221 | (5.69, 8.99, -12.10) | |
| 5:171533739 | rs201487887 | I>V | A:225 | (0.54, 6.63, -13.77) |
| 5:171533735 | T>M | A:226 | (-2.17, 3.42, -11.36) | |
| 5:171533725 | E>D | A:229 | (-4.79, 2.88, -15.22) | |
| 5:171533712 | E>K | A:234 | (-6.26, 3.14, -21.01) | |
| 5:171533701 | rs180852802 | H>Q | A:237 | (1.10, 8.80, -22.90) |
| 5:171533697 | E>K | A:239 | (-2.66, 7.83, -27.43) | |
| 5:171533681 | rs201471238 | R>L | A:244 | (6.84, 8.49, -30.33) |
| 5:171533653 | rs150004028 | D>E | A:253 | (5.01, 18.44, -18.52) |
| 5:171533645 | T>M | A:256 | (-2.99, 15.75, -15.99) | |
| 5:171533639 | L>P | A:258 | (-8.89, 14.52, -19.77) | |
| 5:171533636 | T>M | A:259 | (-12.08, 15.89, -17.13) | |
| 5:171532727 | rs142144816 | R>H | A:268 | (-7.61, 18.23, -9.12) |
| 5:171532728 | rs35826078 | R>C | A:268 | (-7.61, 18.23, -9.12) |
| 5:171532724 | D>A | A:269 | (-2.83, 18.03, -4.67) | |
| 5:171532718 | L>P | A:271 | (-2.02, 13.24, -9.14) | |
| 5:171532712 | rs371584258 | I>T | A:273 | (2.49, 15.78, -4.87) |
| 5:171532703 | D>V | A:276 | (7.74, 15.15, -8.79) | |
| 5:171532700 | K>R | A:277 | (9.69, 14.60, -13.88) | |
| 5:171532701 | COSM13171 | K>E | A:277 | (9.69, 14.60, -13.88) |
| 5:171532679 | rs202191993 | S>T | A:284 | (6.84, 9.31, 0.86) |
| 5:171532673 | A>V | A:286 | (4.41, 8.09, 4.43) | |
| 5:171532674 | rs139973473 | A>T | A:286 | (4.41, 8.09, 4.43) |
| 5:171523563 | H>R | A:291 | (-3.10, 14.11, 0.78) | |
| 5:171523560 | rs545019190 | P>L | A:292 | (-6.06, 15.05, 2.36) |
| 5:171523555 | rs377461679 | V>I | A:294 | (-5.86, 9.01, 1.79) |
| 5:171523548 | rs146021633 | S>N | A:296 | (-9.91, 10.04, 6.09) |
| 5:171523530 | A>D | A:302 | (-16.82, 1.51, -2.73) | |
| 5:171523524 | COSM1065842 | R>Q | A:304 | (-18.09, -4.04, -0.00) |
| 5:171523519 | rs371355194 | L>V | A:306 | (-16.82, -2.21, -8.26) |