General Structure Information
| PDB ID | 2lsp |
| HGNC Gene Label(s) | BRD4 |
| Structure Name | solution structures of brd4 second bromodomain with nf-kb-k310ac peptide |
| Resolution | -1.0Å |
| Reference | AUTH G.ZHANG,R.LIU,Y.ZHONG,A.N.PLOTNIKOV,W.ZHANG,L.ZENG,AUTH 2 E.RUSINOVA,G.GERONA-NEVARRO,N.MOSHKINA,J.JOSHUA,P.Y.CHUANG,AUTH 3 M.OHLMEYER,J.C.HE,M.M.ZHOUTITL DOWN-REGULATION OF NF-KAPPA B TRANSCRIPTIONAL ACTIVITY INTITL 2 HIV-ASSOCIATED KIDNEY DISEASE BY BRD4 INHIBITION.REF J.BIOL.CHEM. V. 287 28840 2012REFN ISSN 0021-9258PMID 22645123DOI 10.1074/JBC.M112.359505 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 128 |
| Number Of SNVs | 19 |
| Number Of Permutations | 11118 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.275 |
| p-value | 0.006 |