2GWH.B | SULT1C4

General Structure Information

PDB ID	2gwh
HGNC Gene Label(s)	SULT1C4
Structure Name	human sulfotranferase sult1c2 in complex with pap and pentachlorophenol
Resolution	1.8Å
Reference	AUTH A.ALLALI-HASSANI,P.W.PAN,L.DOMBROVSKI,R.NAJMANOVICH,AUTH 2 W.TEMPEL,A.DONG,P.LOPPNAU,F.MARTIN,J.THORNTON,J.THONTON,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,M.VEDADI,AUTH 4 C.H.ARROWSMITHTITL STRUCTURAL AND CHEMICAL PROFILING OF THE HUMAN CYTOSOLICTITL 2 SULFOTRANSFERASES.REF PLOS BIOL. V. 5 E97 2007REFN ISSN 1544-9173PMID 17425406DOI 10.1371/JOURNAL.PBIO.0050097

Variant Set Distributions

ExAC Variants

Number Of Residues	288
Number Of SNVs	69
Number Of Permutations	6812
Optimal Distance Threshold	6.0
K Statistic	0.017
p-value	0.388

COSMIC

Number Of Residues	288
Number Of SNVs	6
Number Of Permutations	1068
Optimal Distance Threshold	19.0
K Statistic	0.133
p-value	0.341

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	69
Number Of COSMIC SNVs	6
Optimal Distance Threshold	13.0
K Statistic	-0.133
p-value	0.36

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:108994840	rs570353480	R>H	B:16	(-9.25, 28.25, 68.55)
2:108994857	rs368759234	V>M	B:22	(-27.11, 33.53, 67.50)
2:108994864	rs143817197	G>E	B:24	(-28.03, 33.47, 61.83)
2:108994881	rs554156858	D>N	B:30	(-22.41, 29.63, 75.22)
2:108994882		D>G	B:30	(-22.41, 29.63, 75.22)
2:108994903	rs566330437	K>T	B:37	(-30.99, 39.23, 78.61)
2:108994923	rs536571137	K>E	B:44	(-29.17, 55.67, 78.57)
2:108994939		L>P	B:49	(-23.35, 52.81, 68.91)
2:108998224	rs368540945	T>R	B:59	(-10.33, 50.37, 68.20)
2:108998233		Q>R	B:62	(-13.97, 52.97, 70.15)
2:108998239		I>T	B:64	(-11.83, 59.33, 67.22)
2:108998245	rs145685280	E>V	B:66	(-13.48, 58.75, 74.61)
2:108998252	rs41322445	I>M	B:68	(-14.69, 64.16, 70.00)
2:108998265		D>N	B:73	(-8.97, 64.34, 78.15)
2:108998277		S>G	B:77	(-8.62, 57.71, 77.16)
2:108998283	rs145219467	R>W	B:79	(-10.35, 55.37, 81.66)
2:108998284	rs199882807 COSM4084041	R>Q	B:79	(-10.35, 55.37, 81.66)
2:108998287		A>V	B:80	(-8.51, 51.93, 80.51)
2:108998290	rs78602560	P>R	B:81	(-8.42, 49.17, 78.55)
2:108998302	rs137946991	R>Q	B:85	(-12.03, 52.88, 77.20)
2:108998308		P>L	B:87	(-19.50, 48.56, 76.45)
2:108998316	rs143857621	E>K	B:90	(-22.72, 41.38, 71.03)
2:108998320		M>T	B:91	(-19.10, 40.03, 74.92)
2:108998322		K>E	B:92	(-21.23, 35.27, 76.76)
2:108998323		K>R	B:92	(-21.23, 35.27, 76.76)
2:108998338	COSM3894482	G>V	B:97	(-17.48, 38.52, 80.31)
2:108998873		R>W	B:110	(-24.03, 53.96, 78.14)
2:108998874	rs142885329	R>Q	B:110	(-24.03, 53.96, 78.14)
2:108998888		H>D	B:115	(-19.22, 43.79, 65.67)
2:108998889		H>R	B:115	(-19.22, 43.79, 65.67)
2:108998897	rs369096265	F>L	B:118	(-30.00, 47.78, 61.49)
2:108998920		L>F	B:125	(-30.10, 51.67, 70.42)
2:108998933		C>R	B:130	(-29.06, 56.76, 69.80)
2:108998937		K>T	B:131	(-25.80, 60.38, 68.45)
2:108999555		Y>H	B:134	(-21.40, 51.24, 60.06)
2:108999559		V>E	B:135	(-17.26, 52.15, 60.27)
2:108999561		A>P	B:136	(-16.99, 50.86, 56.48)
2:108999591		Y>D	B:146	(-12.53, 38.47, 60.66)
2:108999603		Q>E	B:150	(-9.98, 34.19, 62.72)
2:108999608		R>S	B:151	(-3.17, 33.84, 62.31)
2:108999609		M>V	B:152	(-4.67, 36.61, 67.31)
2:108999622		L>P	B:156	(-12.58, 33.64, 66.71)
2:108999652		F>S	B:166	(-11.18, 34.17, 49.31)
2:108999669	rs532365323	G>R	B:172	(-20.34, 34.34, 55.51)
2:108999675		V>M	B:174	(-17.67, 34.53, 59.36)
2:108999874		C>R	B:175	(-18.35, 35.60, 63.13)
2:108999875		C>F	B:175	(-18.35, 35.60, 63.13)
2:108999890		H>R	B:180	(-21.28, 41.39, 51.04)
2:108999895	rs185799497	H>Y	B:182	(-23.03, 44.35, 58.48)
2:108999898	rs182424713	V>M	B:183	(-22.33, 47.08, 54.56)
2:108999913		E>K	B:188	(-31.34, 50.40, 53.92)
2:108999941	COSM331957	Y>C	B:197	(-22.00, 54.46, 56.50)
2:108999958		M>V	B:203	(-11.01, 57.54, 58.76)
2:109002668	rs145686853	Q>H	B:212	(-13.68, 68.34, 61.07)
2:109002687		G>R	B:219	(-21.77, 68.41, 69.02)
2:109002693	rs377017374	K>E	B:221	(-17.23, 73.08, 68.92)
2:109002706		K>T	B:225	(-5.50, 74.14, 69.04)
2:109002714	rs142311160	D>N	B:228	(-4.65, 69.20, 64.93)
2:109002715		D>G	B:228	(-4.65, 69.20, 64.93)
2:109002723		V>I	B:231	(-5.22, 63.74, 64.17)
2:109002736	COSM1690878	S>L	B:235	(-2.30, 57.76, 64.73)
2:109002738		F>L	B:236	(-1.28, 52.26, 63.33)
2:109002762	rs372131884	M>V	B:244	(-4.77, 51.56, 77.63)
2:109002769		N>S	B:246	(-2.65, 47.95, 72.02)
2:109002784		P>R	B:251	(-6.30, 37.76, 78.15)
2:109002809		I>M	B:259	(0.26, 34.78, 65.97)
2:109002819		M>L	B:263	(-2.53, 47.57, 66.15)
2:109002823		R>K	B:264	(-1.98, 43.85, 60.46)
2:109003808	rs141659142	V>M	B:277	(-4.97, 38.20, 40.01)
2:109003812	rs372835682	A>V	B:278	(-7.48, 34.98, 40.66)
2:109003816		Q>H	B:279	(-7.94, 35.19, 45.12)
2:109003842		K>R	B:288	(-20.10, 42.77, 40.05)
2:109003847	rs201728224	K>E	B:290	(-23.10, 39.57, 46.75)
2:109003860	COSM400230	T>I	B:294	(-25.93, 49.34, 46.75)
2:109003868	rs373046061	T>S	B:297	(-20.35, 50.63, 45.15)
2:109003877	rs181231789	F>L	B:300	(-16.44, 50.71, 49.47)

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:108998302	COSM200773	R>L	B:85	(-12.03, 52.88, 77.20)
2:108998316	COSM390925	E>K	B:90	(-22.72, 41.38, 71.03)
2:108998328	COSM140995	P>S	B:94	(-14.79, 32.96, 78.59)
2:108999931	COSM1690877	R>C	B:194	(-29.31, 60.36, 65.66)
2:108999932	COSM1005064	R>H	B:194	(-29.31, 60.36, 65.66)
2:109002736	COSM1690878	S>L	B:235	(-2.30, 57.76, 64.73)
2:109002778	COSM1005067	S>L	B:249	(-4.77, 43.94, 78.10)
2:109003876	COSM315683	H>Q	B:299	(-19.32, 55.68, 48.43)

2GWH.B | SULT1C4.

2GWH.B | SULT1C4

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants