3NVQ.E | SEMA7A

General Structure Information

PDB ID 3nvq
HGNC Gene Label(s) SEMA7A
Structure Name molecular mechanism of guidance cue recognition
Resolution 2.4Å
Reference AUTH H.LIU,Z.S.JUO,A.H.SHIM,P.J.FOCIA,X.CHEN,K.C.GARCIA,X.HETITL STRUCTURAL BASIS OF SEMAPHORIN-PLEXIN RECOGNITION AND VIRALTITL 2 MIMICRY FROM SEMA7A AND A39R COMPLEXES WITH PLEXINC1.REF CELL(CAMBRIDGE,MASS.) V. 142 749 2010REFN ISSN 0092-8674PMID 20727575DOI 10.1016/J.CELL.2010.07.040

Variant Set Distributions

ExAC Variants

Number Of Residues 588
Number Of SNVs 137
Number Of Permutations 78654
Optimal Distance Threshold 12.0
K Statistic 0.043
p-value 0.289
ClinVar

Number Of Residues 588
Number Of SNVs 4
Number Of Permutations 1586
Optimal Distance Threshold 6.0
K Statistic 0.167
p-value 0.83
COSMIC

Number Of Residues 588
Number Of SNVs 8
Number Of Permutations 2635
Optimal Distance Threshold 18.0
K Statistic 0.071
p-value 0.929

Ripley’s K Analysis Plots

ExACClinVarCOSMIC

Variant Set Comparisons

ClinVar vs. ExAC

Number Of ExAC SNVs 137
Number Of ClinVar SNVs 4
Optimal Distance Threshold 5.0
K Statistic 0.165
p-value 0.648
Cosmic vs. ExAC

Number Of ExAC SNVs 137
Number Of COSMIC SNVs 10
Optimal Distance Threshold 49.0
K Statistic -0.154
p-value 0.597

Pathogenic Proximity Analysis

ClinVar PathProx Analysis
COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] ClinVar Missense Variants

[+] COSMIC Missense Variants

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