General Structure Information
| PDB ID | 3q32 |
| HGNC Gene Label(s) | JAK2 |
| Structure Name | structure of janus kinase 2 with a pyrrolotriazine inhibitor |
| Resolution | 2.5Å |
| Reference | AUTH L.S.HARIKRISHNAN,M.G.KAMAU,H.WAN,J.A.INGHRIM,K.ZIMMERMANN,AUTH 2 X.SANG,H.A.MASTALERZ,W.L.JOHNSON,G.ZHANG,L.J.LOMBARDO,AUTH 3 M.A.POSS,G.L.TRAINOR,J.S.TOKARSKI,M.V.LORENZI,D.YOU,AUTH 4 M.M.GOTTARDIS,K.F.BALDWIN,J.LIPPY,D.S.NIRSCHL,R.QIU,AUTH 5 A.V.MILLER,J.KHAN,J.S.SACK,A.V.PURANDARETITL PYRROLO[1,2-F]TRIAZINES AS JAK2 INHIBITORS: ACHIEVINGTITL 2 POTENCY AND SELECTIVITY FOR JAK2 OVER JAK3.REF BIOORG.MED.CHEM.LETT. V. 21 1425 2011REFN ISSN 0960-894XPMID 21282055DOI 10.1016/J.BMCL.2011.01.022 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 292 |
| Number Of SNVs | 69 |
| Number Of Permutations | 12333 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.264 |
| p-value | 0.601 |
COSMIC
| Number Of Residues | 292 |
| Number Of SNVs | 5 |
| Number Of Permutations | 2832 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.1 |
| p-value | 0.721 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 69 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.163 |
| p-value | 0.023 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
