General Structure Information
| PDB ID | 4chb |
| HGNC Gene Label(s) | KLHL2 |
| Structure Name | crystal structure of the human klhl2 kelch domain in complex with a wnk4 peptide |
| Resolution | 1.56Å |
| Reference | AUTH F.SCHUMACHER,F.J.SORRELL,D.R.ALESSI,A.N.BULLOCK,T.KURZTITL STRUCTURAL AND BIOCHEMICAL CHARACTERISATION OF THE KLHL3-TITL 2 WNK KINASE INTERACTION IMPORTANT IN BLOOD PRESSURETITL 3 REGULATION.REF BIOCHEM.J. V. 460 237 2014REFN ISSN 0264-6021PMID 24641320DOI 10.1042/BJ20140153 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 286 |
| Number Of SNVs | 34 |
| Number Of Permutations | 3116 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.121 |
| p-value | 0.037 |
COSMIC
| Number Of Residues | 286 |
| Number Of SNVs | 5 |
| Number Of Permutations | 658 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.1 |
| p-value | 0.462 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 34 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | -0.08 |
| p-value | 0.582 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
