General Structure Information
| PDB ID | 3edi |
| HGNC Gene Label(s) | TLL1 |
| Structure Name | crystal structure of tolloid-like protease 1 (tll-1) protease domain |
| Resolution | 1.4Å |
| Reference | AUTH A.MAC SWEENEY,S.G.PARRADO,D.VINZENZ,A.BERNARDI,AUTH 2 A.HEIN,U.BODENDORF,P.ERBEL,C.LOGEL,B.GERHARTZTITL STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OFTITL 2 BONE MORPHOGENETIC PROTEIN 1/TOLLOID-LIKETITL 3 METALLOPROTEASESREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 187 |
| Number Of SNVs | 37 |
| Number Of Permutations | 17532 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.014 |
| p-value | 0.754 |
COSMIC
| Number Of Residues | 187 |
| Number Of SNVs | 8 |
| Number Of Permutations | 4230 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.143 |
| p-value | 0.105 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 37 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | -0.116 |
| p-value | 0.092 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
