General Structure Information
| PDB ID | 2a14 |
| HGNC Gene Label(s) | INMT |
| Structure Name | crystal structure of human indolethylamine n- methyltransferase with sah |
| Resolution | 1.7Å |
| Reference | AUTH H.WU,A.DONG,H.ZENG,P.LOPPNAU,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN INDOLETHYLAMINETITL 2 N-METHYLTRANSFERASE IN COMPLEX WITH SAH.REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 257 |
| Number Of SNVs | 79 |
| Number Of Permutations | 20737 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.034 |
| p-value | 0.189 |
COSMIC
| Number Of Residues | 257 |
| Number Of SNVs | 10 |
| Number Of Permutations | 4351 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.022 |
| p-value | 0.563 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 79 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | -0.015 |
| p-value | 0.676 |