3V6C.A | USP2 – ASTRID

3V6C.A | USP2

General Structure Information

PDB ID	3v6c
HGNC Gene Label(s)	USP2
Structure Name	crystal structure of usp2 in complex with mutated ubiquitin
Resolution	1.7Å
Reference	AUTH M.NECULAI,A.ERNST,S.SIDHU,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 C.BOUNTRA,J.WEIGELT,S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF USP2 IN COMPLEX WITH MUTATED UBIQUITINREF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	327
Number Of SNVs	74
Number Of Permutations	37625
Optimal Distance Threshold	8.0
K Statistic	0.02
p-value	0.062

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
11:119230931		A>V	A:263	(33.75, 61.04, 7.75)
11:119230920		A>T	A:267	(33.52, 51.26, 8.16)
11:119230898	rs537255168	N>S	A:274	(35.14, 33.10, 14.79)
11:119230895		T>M	A:275	(36.03, 36.91, 11.28)
11:119230352		L>V	A:282	(41.15, 44.16, 6.86)
11:119230330	rs149322772	R>Q	A:289	(49.30, 57.11, 3.79)
11:119230310		L>F	A:296	(41.55, 54.16, -3.43)
11:119230293		M>I	A:301	(44.84, 47.69, -12.63)
11:119230294		M>T	A:301	(44.84, 47.69, -12.63)
11:119230295	rs569626060	M>L	A:301	(44.84, 47.69, -12.63)
11:119230291		R>Q	A:302	(51.76, 49.58, -13.37)
11:119230292	COSM923859	R>W	A:302	(51.76, 49.58, -13.37)
11:119230281		H>Q	A:305	(51.78, 40.68, -14.48)
11:119230280	rs201525721	H>Y	A:306	(47.62, 37.55, -15.05)
11:119230277	rs201598684	G>S	A:307	(43.91, 37.77, -14.92)
11:119230270	rs117339295	N>S	A:309	(40.23, 32.87, -11.65)
11:119230267		A>V	A:310	(37.54, 32.50, -8.82)
11:119230253	rs368079550	V>M	A:315	(44.50, 42.07, -5.32)
11:119230044	rs374783359	K>E	A:320	(36.51, 45.42, -4.67)
11:119230029		I>V	A:325	(36.05, 50.92, 3.76)
11:119230022	rs143947394	T>N	A:327	(33.12, 54.91, -0.50)
11:119230010		N>S	A:331	(28.09, 54.04, 11.40)
11:119229992		S>C	A:337	(32.30, 37.70, 2.04)
11:119229959	rs370666027	P>L	A:348	(43.51, 26.79, 2.71)
11:119229960	rs375539156 COSM2106942 COSM2106943	P>S	A:348	(43.51, 26.79, 2.71)
11:119229956		R>H	A:349	(45.96, 27.83, 7.24)
11:119229947		G>V	A:352	(35.83, 28.75, 7.72)
11:119229819	rs377255793 COSM3868569 COSM3868570	R>C	A:363	(52.84, 37.80, 7.17)
11:119229795		N>D	A:371	(53.07, 36.62, -4.81)
11:119229779		V>A	A:376	(59.56, 39.44, -10.40)
11:119229780	rs149464743	V>M	A:376	(59.56, 39.44, -10.40)
11:119229737	rs370403138	L>P	A:390	(82.30, 42.55, 0.28)
11:119229734		P>L	A:391	(82.39, 45.51, 2.93)
11:119229546		D>N	A:392	(79.53, 44.29, 6.65)
11:119229540		E>K	A:394	(78.35, 46.38, -0.58)
11:119229530		R>Q	A:397	(74.60, 48.08, -0.05)
11:119229523		M>I	A:399	(72.15, 39.76, 0.00)
11:119229507		E>Q	A:405	(67.14, 39.49, -8.46)
11:119229503		R>Q	A:406	(64.38, 36.20, -5.14)
11:119229504	rs369164717 COSM428545	R>W	A:406	(64.38, 36.20, -5.14)
11:119229486	rs140569658	G>R	A:412	(57.44, 45.74, -0.16)
11:119228929		T>M	A:424	(81.22, 36.25, 17.21)
11:119228915		G>S	A:429	(86.77, 36.04, 16.20)
11:119228900		V>I	A:434	(73.66, 36.88, 7.98)
11:119228894		D>H	A:436	(67.72, 37.76, 7.21)
11:119228890	rs149216170	P>R	A:437	(64.78, 39.38, 4.60)
11:119228870		P>S	A:444	(60.75, 39.94, 22.86)
11:119228717	rs572954036	D>N	A:466	(72.27, 35.60, 22.48)
11:119228701		D>G	A:471	(72.58, 21.94, 23.19)
11:119228536		R>C	A:478	(86.76, 30.27, 9.80)
11:119228529	rs61753081	R>Q	A:480	(85.81, 22.98, 13.08)
11:119228527		G>R	A:481	(83.77, 23.33, 16.11)
11:119228517	rs566621045	R>Q	A:484	(80.47, 30.95, 24.72)
11:119228518		R>W	A:484	(80.47, 30.95, 24.72)
11:119228514		C>Y	A:485	(78.95, 32.01, 19.93)
11:119228510		I>M	A:486	(78.18, 36.25, 20.73)
11:119228500		S>T	A:490	(71.14, 44.86, 13.42)
11:119228488	COSM3676002 COSM3676003	F>L	A:494	(65.13, 50.86, 9.48)
11:119228480		K>N	A:496	(57.94, 52.95, 4.01)
11:119228479		I>V	A:497	(55.20, 50.26, 7.18)
11:119228470	COSM1351880	L>F	A:500	(56.21, 45.74, 15.91)
11:119228298		L>M	A:502	(54.06, 41.88, 20.96)
11:119228291		R>Q	A:504	(51.29, 39.30, 24.46)
11:119228238		P>S	A:522	(55.35, 54.84, 21.58)
11:119228231	COSM138847	R>T	A:524	(54.30, 61.37, 17.53)
11:119228221		D>E	A:527	(64.28, 56.70, 17.93)
11:119228216	rs202223004	R>K	A:529	(68.41, 57.09, 15.89)
11:119228202		E>K	A:534	(75.30, 51.46, 9.59)
11:119227996	rs149898423	Y>F	A:544	(49.33, 53.10, 11.25)
11:119227991		V>L	A:546	(46.62, 48.61, 17.34)
11:119227963	rs546615860	G>A	A:555	(38.29, 32.76, 22.90)
11:119227958		H>Y	A:557	(37.25, 39.87, 20.12)
11:119227954		Y>C	A:558	(41.72, 39.54, 17.44)
11:119227952	rs528239016	T>A	A:559	(39.93, 44.92, 18.39)
11:119227939	COSM202266	R>H	A:563	(46.57, 57.79, 13.12)
11:119227940	rs139170156	R>C	A:563	(46.57, 57.79, 13.12)
11:119227934		P>S	A:565	(44.96, 58.92, 7.39)
11:119227919	rs201752542	W>R	A:570	(44.04, 56.85, 17.12)
11:119227916	rs150768738	H>Y	A:571	(38.26, 56.19, 15.16)
11:119227912	rs374702113	T>I	A:572	(37.43, 51.61, 18.14)
11:119227908		F>L	A:573	(37.84, 50.30, 13.72)
11:119227596		S>R	A:589	(47.41, 44.97, 27.73)