General Structure Information
| PDB ID | 4i1h |
| HGNC Gene Label(s) | PARK2 |
| Structure Name | structure of parkin e3 ligase |
| Resolution | 2.0Å |
| Reference | AUTH B.E.RILEY,J.C.LOUGHEED,K.CALLAWAY,M.VELASQUEZ,E.BRECHT,AUTH 2 L.NGUYEN,T.SHALER,D.WALKER,Y.YANG,K.REGNSTROM,L.DIEP,AUTH 3 Z.ZHANG,S.CHIOU,M.BOVA,D.R.ARTIS,N.YAO,J.BAKER,T.YEDNOCK,AUTH 4 J.A.JOHNSTONTITL STRUCTURE AND FUNCTION OF PARKIN E3 UBIQUITIN LIGASE REVEALSTITL 2 ASPECTS OF RING AND HECT LIGASES.REF NAT COMMUN V. 4 1982 2013REFN ESSN 2041-1723PMID 23770887DOI 10.1038/NCOMMS2982 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 306 |
| Number Of SNVs | 102 |
| Number Of Permutations | 35937 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.045 |
| p-value | 0.392 |
ClinVar
| Number Of Residues | 306 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1999 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.2 |
| p-value | 0.326 |
COSMIC
| Number Of Residues | 306 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1753 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.133 |
| p-value | 0.639 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 102 |
| Number Of ClinVar SNVs | 6 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.19 |
| p-value | 0.257 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 102 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 43.0 |
| K Statistic | 0.22 |
| p-value | 0.79 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
