General Structure Information
| PDB ID | 4l9m |
| HGNC Gene Label(s) | RASGRP1 |
| Structure Name | autoinhibited state of the ras-specific exchange factor rasgrp1 |
| Resolution | 3.0Å |
| Reference | AUTH J.S.IWIG,Y.VERCOULEN,R.DAS,T.BARROS,A.LIMNANDER,Y.CHE,AUTH 2 J.G.PELTON,D.E.WEMMER,J.P.ROOSE,J.KURIYANTITL STRUCTURAL ANALYSIS OF AUTOINHIBITION IN THE RAS-SPECIFICTITL 2 EXCHANGE FACTOR RASGRP1.REF ELIFE V. 2 00813 2013REFN ESSN 2050-084XPMID 23908768DOI 10.7554/ELIFE.00813 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 522 |
| Number Of SNVs | 87 |
| Number Of Permutations | 28463 |
| Optimal Distance Threshold | 30.0 |
| K Statistic | 0.336 |
| p-value | 0.066 |
COSMIC
| Number Of Residues | 522 |
| Number Of SNVs | 3 |
| Number Of Permutations | 242 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.333 |
| p-value | 0.108 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
