General Structure Information
| PDB ID | 3kxo |
| HGNC Gene Label(s) | HPGDS |
| Structure Name | an orally active inhibitor bound at the active site of hpgds |
| Resolution | 2.1Å |
| Reference | AUTH C.P.CARRON,J.I.TRUJILLO,K.L.OLSON,W.HUANG,B.C.HAMPER,T.DICE,AUTH 2 B.E.NEAL,M.J.PELC,J.DAY,D.C.ROHRER,J.R.KIEFER,J.B.MOON,AUTH 3 B.A.SCHWEITZER,T.D.BLAKE,S.R.TURNER,R.WOERNDLE,B.L.CASE,AUTH 4 C.P.BONO,V.M.DILWORTH,C.L.FUNCKES-SHIPPY,B.L.HOOD,AUTH 5 G.M.JEROME,C.M.KORNMEIER,M.R.RADABAUGH,M.L.WILLIAMS,AUTH 6 M.S.DAVIES,C.D.WEGNER,D.J.WELSCH,W.M.ABRAHAM,C.J.WARREN,AUTH 7 M.E.DOWTY,F.HUA,A.ZUTSHI,J.Z.YANG,A.THORARENSENTITL DISCOVERY OF AN ORAL POTENT SELECTIVE INHIBITOR OFTITL 2 HEMATOPOIETIC PROSTAGLANDIN D SYNTHASEREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 198 |
| Number Of SNVs | 67 |
| Number Of Permutations | 18907 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.04 |
| p-value | 0.349 |
COSMIC
| Number Of Residues | 198 |
| Number Of SNVs | 3 |
| Number Of Permutations | 7 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.333 |
| p-value | 0.814 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 67 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.338 |
| p-value | 0.541 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
