4F91.B | SNRNP200

General Structure Information

PDB ID	4f91
HGNC Gene Label(s)	SNRNP200
Structure Name	brr2 helicase region
Resolution	2.7Å
Reference	AUTH K.F.SANTOS,S.M.JOVIN,G.WEBER,V.PENA,R.LUHRMANN,M.C.WAHLTITL STRUCTURAL BASIS FOR FUNCTIONAL COOPERATION BETWEEN TANDEMTITL 2 HELICASE CASSETTES IN BRR2-MEDIATED REMODELING OF THETITL 3 SPLICEOSOME.REF PROC.NATL.ACAD.SCI.USA V. 109 17418 2012REFN ISSN 0027-8424PMID 23045696DOI 10.1073/PNAS.1208098109

Variant Set Distributions

ExAC Variants

Number Of Residues	1724
Number Of SNVs	243
Number Of Permutations	93182
Optimal Distance Threshold	6.0
K Statistic	0.002
p-value	0.498

ClinVar

Number Of Residues	1724
Number Of SNVs	7
Number Of Permutations	6209
Optimal Distance Threshold	7.0
K Statistic	0.143
p-value	0.0

COSMIC

Ripley’s K Analysis Plots

ExACClinVarCOSMIC

Variant Set Comparisons

ClinVar vs. ExAC

Number Of ExAC SNVs	243
Number Of ClinVar SNVs	7
Optimal Distance Threshold	7.0
K Statistic	0.139
p-value	0.0

Cosmic vs. ExAC

Number Of ExAC SNVs	243
Number Of COSMIC SNVs	11
Optimal Distance Threshold	20.0
K Statistic	-0.048
p-value	0.361

Pathogenic Proximity Analysis

ClinVar PathProx Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:96963262		R>W	B:406	(17.44, -22.91, 14.02)
2:96963198		R>H	B:427	(45.40, 3.85, 14.96)
2:96963162		R>H	B:439	(56.46, 17.55, 35.37)
2:96963138	rs565552426	V>E	B:447	(45.22, 19.11, 24.18)
2:96963132		A>V	B:449	(42.38, 25.42, 22.51)
2:96963117		P>L	B:454	(35.40, 31.53, 11.69)
2:96963108		S>L	B:457	(28.64, 30.20, 4.38)
2:96962775		A>T	B:471	(8.09, 30.73, 20.12)
2:96962768	rs367687155	A>G	B:473	(8.22, 32.30, 24.49)
2:96962754	rs373699900	F>L	B:478	(18.11, 33.66, 25.90)
2:96962750		K>R	B:479	(18.99, 39.66, 22.38)
2:96962739		R>W	B:483	(27.89, 29.06, 15.56)
2:96962724		L>V	B:488	(19.35, 23.36, 14.29)
2:96962718		R>C	B:490	(15.33, 27.08, 8.97)
2:96962702	rs139286118	T>M	B:495	(10.95, 20.24, 10.27)
2:96962695		E>D	B:497	(12.67, 15.16, 9.57)
2:96962400	rs200363070	M>I	B:515	(13.75, 24.68, 19.11)
2:96962398		C>S	B:516	(11.67, 20.47, 18.95)
2:96962395	rs374265902	M>T	B:517	(9.55, 20.62, 22.93)
2:96962389		R>Q	B:519	(6.87, 22.12, 14.84)
2:96962372		I>V	B:525	(-2.59, 27.28, 18.35)
2:96962364	rs148170370	M>I	B:527	(-7.26, 31.93, 18.36)
2:96962350		N>S	B:532	(-5.11, 22.18, 22.71)
2:96962345		D>N	B:534	(-5.67, 17.60, 27.02)
2:96962324	rs552058312	I>V	B:541	(14.71, 9.87, 27.61)
2:96962312		R>C	B:545	(17.37, 8.36, 39.47)
2:96961395		R>H	B:558	(12.61, 28.12, 29.08)
2:96961396		R>C	B:558	(12.61, 28.12, 29.08)
2:96961387		T>A	B:561	(4.20, 31.44, 29.24)
2:96961383		Y>C	B:562	(3.96, 28.40, 26.14)
2:96961381		G>S	B:563	(0.51, 26.04, 30.26)
2:96961334	rs199985246	E>D	B:578	(-4.15, 8.81, 36.36)
2:96961315	rs533005031	I>V	B:585	(6.83, 17.48, 29.25)
2:96961309		V>F	B:587	(11.20, 13.93, 32.45)
2:96961285		I>V	B:595	(9.06, -0.48, 33.48)
2:96961275		R>H	B:598	(8.82, -4.19, 29.74)
2:96961276	rs367922991	R>C	B:598	(8.82, -4.19, 29.74)
2:96961246		L>V	B:608	(-1.30, 11.51, 23.43)
2:96961240		R>W	B:610	(2.54, 12.76, 18.88)
2:96959226		D>N	B:622	(26.63, 2.04, 28.81)
2:96959207		L>S	B:628	(18.23, 3.40, 24.50)
2:96959192		A>V	B:633	(12.48, -0.50, 18.53)
2:96959193		A>T	B:633	(12.48, -0.50, 18.53)
2:96959186		A>G	B:635	(8.76, 3.04, 18.97)
2:96959180	rs539947579 COSM1023890	R>Q	B:637	(6.93, -2.43, 14.32)
2:96959174	rs375172360	I>T	B:639	(5.38, 4.54, 14.21)
2:96959154		V>I	B:646	(6.41, 9.83, 16.53)
2:96959120		N>I	B:657	(29.72, 4.93, 15.04)
2:96959117		Y>C	B:658	(28.11, 10.50, 13.29)
2:96959093		R>H	B:666	(14.26, 5.63, 10.27)
2:96959094	rs200546584	R>C	B:666	(14.26, 5.63, 10.27)
2:96959088		D>N	B:668	(17.67, 12.34, 6.11)
2:96959085		P>S	B:669	(21.46, 12.08, 6.15)
2:96959070		F>I	B:674	(22.62, 18.60, 12.13)
2:96959060	rs371902310	D>G	B:677	(34.19, 20.04, 15.77)
2:96958808		T>A	B:688	(45.76, 18.04, 31.14)
2:96958796		I>V	B:692	(49.81, 7.53, 37.44)
2:96958748	rs191245006	V>I	B:708	(45.22, 19.39, 43.09)
2:96958730		E>Q	B:714	(47.89, 28.51, 37.78)
2:96958715		N>D	B:719	(39.15, 31.88, 38.65)
2:96957613		K>R	B:729	(34.17, 9.70, 51.68)
2:96957584	COSM72750	R>W	B:739	(42.90, 23.04, 54.87)
2:96957576		M>I	B:741	(49.47, 20.51, 52.23)
2:96957567		E>D	B:744	(51.46, 22.48, 55.71)
2:96957523		T>I	B:759	(34.72, 41.33, 49.91)
2:96957227	rs201944329	K>R	B:775	(30.43, 26.99, 59.84)
2:96957216		P>S	B:779	(35.05, 31.33, 56.20)
2:96957194		H>R	B:786	(27.63, 15.80, 49.75)
2:96957153		L>I	B:800	(26.86, 31.58, 47.38)
2:96957148	rs142749600	F>L	B:801	(30.31, 28.51, 42.58)
2:96957134		I>T	B:806	(31.89, 29.69, 46.42)
2:96956460		G>R	B:839	(31.87, -5.93, 42.95)
2:96956456		R>H	B:840	(34.67, -5.13, 39.90)
2:96956433		D>N	B:848	(29.96, 10.10, 34.27)
2:96956141	rs140087655	I>V	B:889	(29.04, 4.57, 19.63)
2:96956107		M>T	B:900	(15.58, -6.91, 26.02)
2:96956090		V>M	B:906	(5.32, -10.52, 27.16)
2:96956065	COSM3972397	K>R	B:914	(10.48, -14.61, 10.87)
2:96955731		A>T	B:916	(12.69, -11.99, 16.35)
2:96955719		L>M	B:920	(17.37, -8.10, 16.14)
2:96955692		M>V	B:929	(26.36, -6.75, 13.10)
2:96955677	rs149616320	T>A	B:934	(35.26, -7.87, 12.32)
2:96955655	rs372777445	D>G	B:941	(33.66, -14.87, 4.33)
2:96955656	rs545475705	D>N	B:941	(33.66, -14.87, 4.33)
2:96955643		G>A	B:945	(26.12, -14.26, 1.61)
2:96955627		D>E	B:950	(19.37, -13.81, 7.72)
2:96955623	COSM3783450	R>C	B:952	(25.21, -13.82, 13.97)
2:96955619	COSM1023884	R>Q	B:953	(19.04, -11.40, 12.31)
2:96955608	rs559479531	V>I	B:957	(17.00, -15.57, 18.58)
2:96955595		A>V	B:961	(15.26, -19.05, 23.40)
2:96955596		A>S	B:961	(15.26, -19.05, 23.40)
2:96955560		D>N	B:973	(9.07, -25.49, 19.48)
2:96955544		N>T	B:978	(6.34, -20.90, 18.75)
2:96955117		V>M	B:981	(4.14, -16.42, 27.39)
2:96955108		L>V	B:984	(7.51, -17.12, 35.64)
2:96955104		G>V	B:985	(7.77, -14.01, 32.21)
2:96955077		T>I	B:994	(17.14, -11.61, 35.45)
2:96955074	rs143494993	N>S	B:995	(16.49, -15.01, 33.06)
2:96955053	rs143529458	N>S	B:1002	(10.33, -21.71, 40.08)
2:96955011	rs376963853	R>T	B:1016	(18.77, -17.96, 51.40)
2:96954976		T>A	B:1028	(31.70, -9.78, 47.72)
2:96954842		E>G	B:1036	(29.75, -2.74, 60.04)
2:96954819		V>L	B:1044	(18.59, -7.41, 62.68)
2:96954816		P>T	B:1045	(14.99, -9.00, 63.32)
2:96954794		I>T	B:1052	(28.77, -17.54, 57.97)
2:96954478		V>I	B:1061	(21.87, -8.10, 57.00)
2:96954418		M>V	B:1081	(22.13, -0.50, 51.73)
2:96954411	COSM1615271	Y>C	B:1083	(22.55, -2.87, 43.68)
2:96953706	rs267607077 CM097780	S>L	B:1087	(16.07, -3.54, 44.00)
2:96953697	rs397514574 CM100404	R>Q	B:1090	(12.03, -4.13, 40.91)
2:96953692	rs370783235	M>V	B:1092	(9.46, -8.91, 47.29)
2:96953688		R>Q	B:1093	(4.81, -5.95, 44.89)
2:96953686	COSM576393	A>P	B:1094	(7.63, -10.35, 41.85)
2:96953680		F>L	B:1096	(2.44, -10.44, 45.83)
2:96953664		N>S	B:1101	(-1.26, -16.76, 40.17)
2:96953661		R>Q	B:1102	(1.94, -20.31, 41.88)
2:96953658		G>D	B:1103	(-2.64, -19.48, 46.04)
2:96953627		N>K	B:1113	(3.55, -7.58, 54.79)
2:96953611		D>N	B:1119	(7.43, 1.41, 50.95)
2:96953264		R>W	B:1133	(5.80, 11.26, 56.23)
2:96953233		I>T	B:1143	(2.54, 3.85, 71.53)
2:96953186		N>D	B:1159	(-8.42, 12.93, 77.35)
2:96953179	rs202181016	I>S	B:1161	(-4.66, 8.74, 73.97)
2:96952845		L>V	B:1180	(-6.55, 9.62, 58.88)
2:96952823		S>L	B:1187	(-20.96, -7.37, 54.33)
2:96952806		I>V	B:1193	(-25.53, -21.13, 41.88)
2:96952800		R>C	B:1195	(-24.49, -29.67, 45.60)
2:96952769	rs376746667	T>M	B:1205	(-18.35, 0.05, 54.30)
2:96952608		G>D	B:1216	(-5.39, 10.90, 47.93)
2:96952567	rs372772120	S>G	B:1230	(-5.77, -19.92, 55.57)
2:96952563		E>G	B:1231	(-3.65, -23.84, 53.54)
2:96952560		V>G	B:1232	(-6.04, -21.88, 49.42)
2:96952558		I>V	B:1233	(-6.07, -17.81, 47.45)
2:96952547		H>Q	B:1236	(-7.40, -12.97, 43.40)
2:96952549	COSM722843	H>Y	B:1236	(-7.40, -12.97, 43.40)
2:96952506	rs548219706	H>R	B:1250	(-18.38, 0.43, 47.25)
2:96952503	rs371914687	L>R	B:1251	(-21.75, -4.72, 45.63)
2:96952498	rs531287899	T>A	B:1253	(-20.02, -9.68, 42.53)
2:96952434		R>H	B:1274	(1.17, 1.18, 49.08)
2:96952435		R>C	B:1274	(1.17, 1.18, 49.08)
2:96952428	rs562616308	L>H	B:1276	(1.80, -2.01, 57.40)
2:96952217	rs370235055	E>K	B:1279	(-6.23, -7.25, 57.55)
2:96952111		N>S	B:1314	(-45.99, -31.57, 2.34)
2:96952109		S>G	B:1315	(-44.22, -31.25, -1.38)
2:96952106		A>S	B:1316	(-44.74, -27.58, 0.10)
2:96952096		S>N	B:1319	(-39.63, -26.24, -0.62)
2:96952083	rs541824473	D>E	B:1323	(-33.06, -25.52, -2.29)
2:96952059		I>M	B:1331	(-30.31, -31.77, 17.80)
2:96951051		D>G	B:1344	(-46.98, -33.48, 22.68)
2:96951048	rs566448118	N>S	B:1345	(-46.19, -30.28, 25.62)
2:96951013		T>A	B:1357	(-35.62, -21.81, 14.74)
2:96951008		I>M	B:1358	(-36.09, -25.63, 12.38)
2:96950973	rs114028687	Q>L	B:1370	(-54.05, -30.98, 11.84)
2:96950969		S>R	B:1371	(-55.43, -25.95, 10.72)
2:96950967		S>L	B:1372	(-56.88, -24.16, 7.88)
2:96950963		E>D	B:1373	(-57.50, -19.58, 9.34)
2:96950958		R>H	B:1375	(-54.69, -18.05, 15.96)
2:96950959		R>C	B:1375	(-54.69, -18.05, 15.96)
2:96950947		I>V	B:1379	(-42.96, -15.34, 22.64)
2:96950934		E>A	B:1383	(-37.51, -5.82, 19.71)
2:96950323	rs143898031	V>I	B:1389	(-38.25, -14.52, 13.36)
2:96950307		Y>F	B:1394	(-44.05, -11.89, 5.22)
2:96950283	rs560485569	N>S	B:1402	(-49.70, -17.84, 0.99)
2:96950269		L>V	B:1407	(-44.84, -7.88, 14.49)
2:96950257	rs185671719	E>K	B:1411	(-51.24, 1.00, 19.31)
2:96950218		I>V	B:1424	(-47.85, -17.00, 12.70)
2:96950202		P>H	B:1429	(-42.93, -10.69, 26.45)
2:96950203	rs200737497	P>A	B:1429	(-42.93, -10.69, 26.45)
2:96950145		I>S	B:1448	(-53.91, -20.59, 20.90)
2:96950142	rs575003767 COSM4096369	N>S	B:1449	(-53.78, -24.33, 18.09)
2:96950128	rs561328120	D>H	B:1454	(-37.11, -18.83, 21.86)
2:96950115		L>P	B:1458	(-33.71, -15.10, 29.11)
2:96950112		I>T	B:1459	(-36.81, -17.14, 33.14)
2:96950113		I>F	B:1459	(-36.81, -17.14, 33.14)
2:96950097		G>E	B:1464	(-38.21, -12.75, 33.17)
2:96949687		R>Q	B:1483	(-61.18, -27.37, 24.41)
2:96949651		S>F	B:1495	(-28.86, -27.80, 34.70)
2:96949648	COSM1669142	N>S	B:1496	(-32.41, -26.61, 35.85)
2:96949645		A>V	B:1497	(-34.65, -28.86, 32.61)
2:96949574	rs191776366	V>I	B:1521	(-20.47, -27.13, 14.91)
2:96949559		H>N	B:1526	(-9.37, -20.89, 23.25)
2:96949442		I>V	B:1532	(-5.27, -5.38, 33.51)
2:96949436		H>Y	B:1534	(-7.90, 0.86, 34.50)
2:96949400		V>M	B:1546	(-7.47, -9.45, 18.60)
2:96949375	rs143666966	S>L	B:1554	(-9.30, -17.33, 11.42)
2:96949358		I>V	B:1560	(-17.50, -11.79, 14.79)
2:96949327	rs201294843	R>H	B:1570	(-14.16, 4.23, 15.06)
2:96949328	rs201501591	R>C	B:1570	(-14.16, 4.23, 15.06)
2:96949315	rs199736893	I>T	B:1574	(-8.72, 1.55, 12.78)
2:96949068		D>N	B:1596	(-16.34, -5.77, -6.82)
2:96949031		T>M	B:1608	(-14.57, 5.44, 8.59)
2:96949008		G>R	B:1616	(-12.04, -5.83, 5.21)
2:96949005		V>L	B:1617	(-12.79, -4.38, 8.33)
2:96948974	rs201927374	M>T	B:1627	(-28.75, 0.77, 5.10)
2:96948975	rs556669919	M>V	B:1627	(-28.75, 0.77, 5.10)
2:96948968		R>Q	B:1629	(-27.19, -2.08, 11.13)
2:96948965		R>H	B:1630	(-30.05, -3.40, 5.97)
2:96948944		S>I	B:1637	(-22.34, -13.35, 4.53)
2:96947639		A>G	B:1646	(-19.50, -5.49, 17.21)
2:96947633	rs200426430	R>Q	B:1648	(-23.11, -5.27, 24.91)
2:96947634	rs377595031	R>W	B:1648	(-23.11, -5.27, 24.91)
2:96947610	rs142585893	V>M	B:1656	(-24.00, -12.93, 10.89)
2:96947595	rs376199066	V>L	B:1661	(-16.22, -15.37, 18.09)
2:96947588	rs145701974	I>T	B:1663	(-15.63, -11.89, 23.52)
2:96947589	rs372940792	I>V	B:1663	(-15.63, -11.89, 23.52)
2:96947567		N>S	B:1670	(-23.10, 1.57, 35.83)
2:96947552	rs541112526	A>V	B:1675	(-18.86, 0.75, 37.96)
2:96947553		A>T	B:1675	(-18.86, 0.75, 37.96)
2:96945245	rs375062852	R>C	B:1693	(-19.32, -21.13, 8.88)
2:96945238		L>S	B:1695	(-22.94, -25.46, 5.44)
2:96945230	COSM576398	D>N	B:1698	(-15.31, -29.05, 10.18)
2:96945226		E>A	B:1699	(-13.80, -26.11, 13.06)
2:96945199		G>D	B:1708	(-8.95, -12.85, 35.70)
2:96944725		K>N	B:1715	(-12.84, -22.38, 32.78)
2:96944636		I>T	B:1745	(-56.44, -12.74, 42.40)
2:96944618		A>V	B:1751	(-52.52, -15.77, 45.32)
2:96944585		R>H	B:1762	(-42.32, -25.79, 40.18)
2:96944555		N>T	B:1772	(-33.75, -16.16, 52.13)
2:96944437		R>H	B:1779	(-42.88, -26.62, 57.84)
2:96944369		I>V	B:1802	(-55.34, -3.39, 46.80)
2:96944351		M>L	B:1808	(-60.07, -13.42, 53.18)
2:96944345		V>M	B:1810	(-58.71, -8.70, 47.32)
2:96944318		A>T	B:1819	(-51.85, 0.56, 36.26)
2:96944306		Y>H	B:1823	(-47.85, -3.07, 31.37)
2:96944066		T>I	B:1840	(-49.64, 21.16, 38.54)
2:96944040		I>V	B:1849	(-43.20, 11.95, 33.54)
2:96944033		N>S	B:1851	(-39.51, 10.96, 38.63)
2:96944034		N>H	B:1851	(-39.51, 10.96, 38.63)
2:96943990		D>E	B:1865	(-20.76, 12.75, 33.57)
2:96943676		V>I	B:1875	(-32.48, 23.30, 28.64)
2:96943639		P>L	B:1887	(-31.84, 8.17, 35.83)
2:96943634	rs200367764	V>I	B:1889	(-31.82, 14.24, 35.92)
2:96943598		R>C	B:1901	(-37.64, 20.47, 17.09)
2:96943585		S>T	B:1905	(-25.53, 11.55, 21.07)
2:96943564	COSM1532930	T>M	B:1912	(-34.81, 10.03, 23.47)
2:96943410		N>S	B:1933	(-58.55, 14.07, 41.99)
2:96943399		S>G	B:1937	(-55.97, 23.54, 34.70)
2:96943375		L>V	B:1945	(-47.23, 17.11, 27.51)
2:96943315		H>Y	B:1965	(-39.35, 21.00, 5.48)
2:96943297		I>V	B:1971	(-42.10, 31.49, 11.77)
2:96943290	COSM1023864	R>H	B:1973	(-40.32, 37.53, 6.52)
2:96942978	rs75956769	G>A	B:1978	(-50.53, 36.88, 9.68)
2:96942979		G>R	B:1978	(-50.53, 36.88, 9.68)
2:96942975		V>A	B:1979	(-49.45, 33.53, 9.03)
2:96942955		M>V	B:1986	(-55.66, 25.31, 4.77)
2:96942928	rs201691299	A>T	B:1995	(-45.13, 32.96, -2.46)
2:96942924		L>S	B:1996	(-44.72, 33.33, 1.87)
2:96942886		R>C	B:2009	(-48.76, 13.96, 3.57)
2:96942862		I>V	B:2017	(-62.87, 18.25, 13.75)
2:96942841	rs376585390	V>I	B:2024	(-80.74, 16.16, 27.36)
2:96942829		S>G	B:2028	(-86.24, 19.03, 33.08)
2:96942823	rs150442718	R>C	B:2030	(-84.01, 20.00, 40.58)
2:96942719	COSM117360	G>R	B:2033	(-79.43, 15.42, 39.51)
2:96942710		V>M	B:2036	(-77.17, 14.10, 29.72)
2:96942673		T>I	B:2048	(-56.42, 7.12, 5.28)
2:96942653		L>V	B:2055	(-39.75, 14.50, 15.65)
2:96942650		F>L	B:2056	(-43.28, 9.97, 18.54)
2:96941083		R>H	B:2060	(-49.47, 8.10, 18.40)
2:96940866	rs140574531	T>A	B:2099	(-79.22, 28.01, 42.54)
2:96940853		N>S	B:2103	(-71.59, 29.45, 33.59)
2:96940791	rs377640627	V>M	B:2124	(-77.58, 24.60, 32.88)

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:96959219	rs527236115	R>K	B:624	(22.20, 2.56, 31.34)
2:96958828	rs527236113	R>H	B:681	(33.27, 23.65, 24.25)
2:96958823	rs527236114	V>L	B:683	(34.29, 27.79, 26.46)
2:96956213	rs786205529	G>S	B:865	(39.47, 26.58, 29.71)
2:96956153	rs397514575	Q>E	B:885	(35.93, 13.90, 18.35)
2:96953706	rs267607077	S>L	B:1087	(16.07, -3.54, 44.00)
2:96953697	rs397514574	R>L	B:1090	(12.03, -4.13, 40.91)

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:96959180	COSM1023890	R>Q	B:637	(6.93, -2.43, 14.32)
2:96957583	COSM1410040	R>Q	B:739	(42.90, 23.04, 54.87)
2:96957584	COSM72750	R>W	B:739	(42.90, 23.04, 54.87)
2:96956189	COSM1752731	H>Y	B:873	(50.08, 5.37, 31.78)
2:96955685	COSM1615272	R>P	B:931	(27.68, -0.06, 8.69)
2:96955584	COSM1669144	D>Y	B:965	(13.05, -23.09, 27.54)
2:96954411	COSM1615271	Y>C	B:1083	(22.55, -2.87, 43.68)
2:96953198	COSM1227002	D>N	B:1155	(-12.27, 2.24, 71.47)
2:96952745	COSM76535	K>R	B:1213	(-2.74, 16.20, 52.75)
2:96952163	COSM1690787	P>S	B:1297	(-27.96, -36.56, 33.49)
2:96950164	COSM1023876	R>C	B:1442	(-58.91, -9.58, 25.06)
2:96949427	COSM4594071	T>P	B:1537	(-5.54, -0.34, 30.41)
2:96949346	COSM722846	P>S	B:1564	(-17.64, -3.04, 24.85)
2:96944664	COSM1565924	F>L	B:1736	(-50.31, -10.69, 42.51)
2:96944599	COSM1196369	W>C	B:1757	(-50.37, -23.27, 37.29)
2:96944582	COSM304374	R>H	B:1763	(-35.32, -24.07, 41.54)
2:96944019	COSM1752730	E>K	B:1856	(-34.47, 3.63, 37.51)
2:96942927	COSM241703	A>V	B:1995	(-45.13, 32.96, -2.46)

4F91.B | SNRNP200.

4F91.B | SNRNP200

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] ClinVar Missense Variants

[+] COSMIC Missense Variants