General Structure Information
| PDB ID | 3hu6 |
| HGNC Gene Label(s) | SPOP |
| Structure Name | structures of spop-substrate complexes: insights into molecular architectures of btb-cul3 ubiquitin ligases: spopmathx/btb/3-box-pucsbc1 |
| Resolution | 2.7Å |
| Reference | AUTH M.ZHUANG,M.F.CALABRESE,J.LIU,M.B.WADDELL,A.NOURSE,AUTH 2 M.HAMMEL,D.J.MILLER,H.WALDEN,D.M.DUDA,S.N.SEYEDIN,AUTH 3 T.HOGGARD,J.W.HARPER,K.P.WHITE,B.A.SCHULMANTITL STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTSTITL 2 INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITINTITL 3 LIGASES.REF MOL.CELL V. 36 39 2009REFN ISSN 1097-2765PMID 19818708DOI 10.1016/J.MOLCEL.2009.09.022 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 283 |
| Number Of SNVs | 11 |
| Number Of Permutations | 3586 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | 0.8 |
| p-value | 0.022 |
COSMIC
| Number Of Residues | 283 |
| Number Of SNVs | 11 |
| Number Of Permutations | 1007 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.218 |
| p-value | 0.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 11 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.321 |
| p-value | 0.24 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
