General Structure Information
| PDB ID | 2hrb |
| HGNC Gene Label(s) | CBR3 |
| Structure Name | crystal structure of human carbonyl reductase 3, complexed with nadp+ |
| Resolution | 1.9Å |
| Reference | AUTH E.S.PILKA,A.ROJKOVA,K.L.KAVANAGH,F.NIESEN,M.SUNDSTROM,AUTH 2 C.ARROWSMITH,J.WEIGELT,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN CARBONYL REDUCTASE 3, COMPLEXEDTITL 2 WITH NADP+REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 272 |
| Number Of SNVs | 78 |
| Number Of Permutations | 11896 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.044 |
| p-value | 0.878 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 21:37507506 | R>C | A:6 | (-8.32, 8.76, 10.39) | |
| 21:37507524 | G>R | A:12 | (7.70, 21.57, 13.48) | |
| 21:37507528 | A>D | A:13 | (4.92, 22.82, 11.66) | |
| 21:37507533 | rs574795759 | R>G | A:15 | (10.27, 27.09, 10.43) |
| 21:37507534 | R>K | A:15 | (10.27, 27.09, 10.43) | |
| 21:37507585 | D>V | A:32 | (-8.45, 15.97, 11.68) | |
| 21:37507587 | rs563525294 | V>M | A:33 | (-4.22, 17.85, 10.38) |
| 21:37507593 | COSM4101445 | L>F | A:35 | (0.16, 22.57, 13.05) |
| 21:37507608 | V>M | A:40 | (1.80, 29.55, 20.01) | |
| 21:37507611 | A>T | A:41 | (2.59, 32.63, 17.40) | |
| 21:37507621 | Q>P | A:44 | (-2.06, 29.83, 15.96) | |
| 21:37507629 | V>M | A:47 | (-3.00, 27.53, 11.16) | |
| 21:37507630 | V>E | A:47 | (-3.00, 27.53, 11.16) | |
| 21:37507643 | rs112226760 | Q>H | A:51 | (-7.08, 28.85, 7.98) |
| 21:37507645 | rs149600444 | A>E | A:52 | (-5.90, 31.19, 3.47) |
| 21:37507650 | G>S | A:54 | (-8.62, 26.42, 2.62) | |
| 21:37507660 | P>L | A:57 | (-5.52, 23.16, 10.16) | |
| 21:37507666 | F>C | A:59 | (-2.06, 24.79, 17.43) | |
| 21:37507667 | F>L | A:59 | (-2.06, 24.79, 17.43) | |
| 21:37507701 | R>G | A:71 | (3.59, 13.17, 29.54) | |
| 21:37507704 | A>T | A:72 | (-0.49, 17.36, 26.88) | |
| 21:37507705 | A>D | A:72 | (-0.49, 17.36, 26.88) | |
| 21:37507710 | R>C | A:74 | (-0.36, 11.51, 26.52) | |
| 21:37507715 | D>E | A:75 | (-3.53, 13.75, 27.58) | |
| 21:37507719 | rs144228729 | L>M | A:77 | (-4.35, 12.98, 20.83) |
| 21:37507720 | L>P | A:77 | (-4.35, 12.98, 20.83) | |
| 21:37507725 | K>E | A:79 | (-10.32, 14.20, 25.63) | |
| 21:37507734 | G>W | A:82 | (-8.29, 7.91, 21.04) | |
| 21:37507737 | rs377655909 | G>R | A:83 | (-5.60, 8.85, 19.45) |
| 21:37507740 | rs9282628 | L>V | A:84 | (-2.19, 9.14, 16.78) |
| 21:37510135 | M>T | A:101 | (28.01, 26.81, 20.56) | |
| 21:37510147 | I>T | A:105 | (27.06, 22.93, 24.60) | |
| 21:37510157 | rs368106883 | E>D | A:108 | (24.12, 18.75, 25.66) |
| 21:37510158 | M>L | A:109 | (21.88, 21.16, 23.44) | |
| 21:37510159 | M>T | A:109 | (21.88, 21.16, 23.44) | |
| 21:37510176 | F>V | A:115 | (18.06, 10.39, 20.34) | |
| 21:37510177 | F>S | A:115 | (18.06, 10.39, 20.34) | |
| 21:37510185 | T>P | A:118 | (12.49, 12.12, 18.84) | |
| 21:37510186 | rs144087608 | T>I | A:118 | (12.49, 12.12, 18.84) |
| 21:37510195 | rs375932579 | M>T | A:121 | (7.37, 12.30, 20.93) |
| 21:37510197 | rs146500734 | C>S | A:122 | (8.13, 7.75, 20.23) |
| 21:37510203 | rs200786415 COSM1030479 |
E>K | A:124 | (4.98, 9.36, 26.01) |
| 21:37510206 | L>I | A:125 | (2.67, 9.41, 21.31) | |
| 21:37510210 | L>P | A:126 | (4.13, 4.29, 19.91) | |
| 21:37510213 | rs140773531 | P>L | A:127 | (1.27, 3.91, 23.36) |
| 21:37510219 | M>T | A:129 | (-0.30, 4.97, 17.47) | |
| 21:37510224 | rs16993929 | P>S | A:131 | (-4.66, 0.19, 14.60) |
| 21:37510225 | P>L | A:131 | (-4.66, 0.19, 14.60) | |
| 21:37510230 | rs369860904 | G>R | A:133 | (-0.22, 3.27, 11.80) |
| 21:37518377 | rs369768555 COSM1030480 |
R>I | A:134 | (1.40, 4.11, 9.22) |
| 21:37518380 | V>A | A:135 | (5.80, 6.62, 12.77) | |
| 21:37518391 | rs554918969 | S>C | A:139 | (16.59, 11.90, 9.32) |
| 21:37518399 | L>F | A:141 | (21.27, 11.12, 3.58) | |
| 21:37518411 | R>S | A:145 | (30.38, 10.81, 5.79) | |
| 21:37518424 | C>R | A:150 | (32.35, 5.88, 12.81) | |
| 21:37518435 | D>E | A:153 | (33.69, -0.46, 17.03) | |
| 21:37518447 | R>S | A:157 | (29.28, -0.78, 19.43) | |
| 21:37518449 | rs372587458 | F>Y | A:158 | (25.43, 2.65, 15.93) |
| 21:37518454 | S>G | A:160 | (23.40, -4.67, 15.44) | |
| 21:37518456 | rs377090354 | S>R | A:160 | (23.40, -4.67, 15.44) |
| 21:37518491 | M>T | A:172 | (23.77, 8.79, 21.62) | |
| 21:37518524 | V>A | A:183 | (37.73, 12.02, 24.30) | |
| 21:37518541 | W>R | A:189 | (31.62, 8.94, 18.74) | |
| 21:37518544 | P>S | A:190 | (31.92, 11.60, 14.33) | |
| 21:37518553 | P>S | A:193 | (26.83, 16.83, 16.26) | |
| 21:37518560 | G>A | A:195 | (24.77, 13.17, 12.47) | |
| 21:37518571 | L>M | A:199 | (22.88, 7.48, 13.34) | |
| 21:37518604 | R>G | A:210 | (13.55, -5.35, 16.72) | |
| 21:37518607 | R>C | A:211 | (9.18, -1.27, 20.94) | |
| 21:37518608 | rs141949108 | R>H | A:211 | (9.18, -1.27, 20.94) |
| 21:37518616 | E>K | A:214 | (8.43, -8.21, 20.49) | |
| 21:37518631 | D>N | A:219 | (-1.74, -3.31, 15.69) | |
| 21:37518632 | D>G | A:219 | (-1.74, -3.31, 15.69) | |
| 21:37518635 | R>K | A:220 | (-0.33, -4.37, 9.87) | |
| 21:37518650 | rs576089419 | A>V | A:225 | (13.28, 6.83, 8.52) |
| 21:37518656 | C>F | A:227 | (15.69, 11.36, 3.97) | |
| 21:37518661 | rs369106912 | G>R | A:229 | (16.63, 15.77, 1.01) |
| 21:37518667 | rs532469138 | V>L | A:231 | (17.33, 21.30, 0.11) |
| 21:37518683 | D>G | A:236 | (18.63, 34.63, -0.31) | |
| 21:37518700 | R>G | A:242 | (9.67, 24.27, -6.63) | |
| 21:37518706 | rs1056892 | V>M | A:244 | (10.81, 22.92, 1.05) |
| 21:37518718 | A>T | A:248 | (7.13, 16.36, 1.76) | |
| 21:37518725 | rs548362820 | T>N | A:250 | (9.22, 10.65, 1.26) |
| 21:37518728 | rs370219967 | P>L | A:251 | (7.56, 12.37, 4.34) |
| 21:37518751 | P>T | A:259 | (-3.73, -0.45, 5.10) | |
| 21:37518760 | rs141918656 | T>A | A:262 | (4.34, -5.25, 5.26) |
| 21:37518785 | H>L | A:270 | (16.08, 9.58, -0.40) | |
| 21:37518788 | D>G | A:271 | (13.54, 9.86, -3.17) | |
| 21:37518791 | K>R | A:272 | (9.32, 7.28, -2.47) | |
| 21:37518801 | rs375409364 | Q>H | A:275 | (18.64, 4.18, 1.74) |