General Structure Information
| PDB ID | 1vzo |
| HGNC Gene Label(s) | RPS6KA5 |
| Structure Name | the structure of the n-terminal kinase domain of msk1 reveals a novel autoinhibitory conformation for a dual kinase protein |
| Resolution | 1.8Å |
| Reference | AUTH K.J.SMITH,P.S.CARTER,A.BRIDGES,P.HORROCKS,C.LEWIS,AUTH 2 G.PETTMAN,A.CLARKE,M.BROWN,J.HUGHES,M.WILKINSON,AUTH 3 B.BAX,A.REITHTITL THE STRUCTURE OF MSK1 REVEALS A NOVELTITL 2 AUTOINHIBITORY CONFORMATION FOR A DUAL KINASETITL 3 PROTEINREF STRUCTURE V. 12 1066 2004REFN ISSN 0969-2126PMID 15274926DOI 10.1016/J.STR.2004.02.040 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 319 |
| Number Of SNVs | 55 |
| Number Of Permutations | 24974 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.038 |
| p-value | 0.333 |
COSMIC
| Number Of Residues | 319 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1212 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.1 |
| p-value | 0.44 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 55 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.085 |
| p-value | 0.553 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
