General Structure Information
| PDB ID | 3ulv |
| HGNC Gene Label(s) | TLR3 |
| Structure Name | structure of quaternary complex of human tlr3ecd with three fabs (form2) |
| Resolution | 3.52Å |
| Reference | AUTH J.LUO,G.OBMOLOVA,T.J.MALIA,S.J.WU,K.E.DUFFY,J.D.MARION,AUTH 2 J.K.BELL,P.GE,Z.H.ZHOU,A.TEPLYAKOV,Y.ZHAO,R.J.LAMB,AUTH 3 J.L.JORDAN,L.R.SAN MATEO,R.W.SWEET,G.L.GILLILANDTITL LATERAL CLUSTERING OF TLR3:DSRNA SIGNALING UNITS REVEALED BYTITL 2 TLR3ECD:3FABS QUATERNARY STRUCTURE.REF J.MOL.BIOL. V. 421 112 2012REFN ISSN 0022-2836PMID 22579623DOI 10.1016/J.JMB.2012.05.006 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 668 |
| Number Of SNVs | 154 |
| Number Of Permutations | 34750 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.313 |
| p-value | 0.106 |
COSMIC
| Number Of Residues | 668 |
| Number Of SNVs | 8 |
| Number Of Permutations | 3485 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.036 |
| p-value | 0.976 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 154 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | -0.07 |
| p-value | 0.816 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 4:186997882 | C>R | A:37 | (-57.15, 39.82, 4.75) | |
| 4:186997899 | COSM3775735 | L>F | A:42 | (-62.74, 39.55, 9.01) |
| 4:186997912 | D>N | A:47 | (-60.80, 50.86, 8.94) | |
| 4:186997913 | D>V | A:47 | (-60.80, 50.86, 8.94) | |
| 4:186997934 | T>R | A:54 | (-54.98, 48.00, -6.16) | |
| 4:186997949 | rs143307508 | T>N | A:59 | (-60.23, 34.42, 1.09) |
| 4:186997953 | H>Q | A:60 | (-61.57, 31.19, 3.40) | |
| 4:186997956 | N>K | A:61 | (-63.65, 35.57, 5.93) | |
| 4:186997964 | R>K | A:64 | (-74.62, 39.39, 7.20) | |
| 4:186997982 | N>S | A:70 | (-67.37, 50.26, 4.56) | |
| 4:186997988 | T>I | A:72 | (-65.55, 55.42, -0.01) | |
| 4:186998017 | rs370564831 | V>I | A:82 | (-65.05, 38.03, -1.34) |
| 4:186998018 | rs557548506 COSM1539764 |
V>A | A:82 | (-65.05, 38.03, -1.34) |
| 4:186998020 | G>R | A:83 | (-64.43, 34.18, -0.91) | |
| 4:186998029 | T>S | A:86 | (-71.84, 34.57, 4.67) | |
| 4:186998030 | T>I | A:86 | (-71.84, 34.57, 4.67) | |
| 4:186998068 | P>A | A:99 | (-64.20, 52.60, -10.81) | |
| 4:186998071 | rs150769655 | M>L | A:100 | (-60.25, 50.98, -11.35) |
| 4:186998089 | L>F | A:106 | (-68.41, 36.57, -5.77) | |
| 4:186998093 | Q>P | A:107 | (-65.41, 31.49, -4.90) | |
| 4:186998096 | H>R | A:108 | (-68.37, 28.71, -1.17) | |
| 4:186998098 | N>D | A:109 | (-70.61, 33.05, -1.29) | |
| 4:186998101 | E>K | A:110 | (-75.08, 32.51, 1.45) | |
| 4:186998111 | rs559783546 | Q>P | A:113 | (-81.54, 35.79, -6.25) |
| 4:186998119 | rs140176180 | D>N | A:116 | (-80.97, 44.12, -13.51) |
| 4:186998126 | T>I | A:118 | (-76.16, 43.51, -8.80) | |
| 4:186998141 | rs202236935 | T>M | A:123 | (-68.80, 48.81, -16.65) |
| 4:186998159 | H>R | A:129 | (-64.90, 34.37, -10.82) | |
| 4:186998183 | K>R | A:137 | (-83.61, 30.15, -12.47) | |
| 4:186998194 | N>D | A:141 | (-80.73, 41.37, -18.45) | |
| 4:186998210 | Q>R | A:146 | (-71.30, 43.76, -17.41) | |
| 4:187000003 | T>S | A:151 | (-64.24, 35.26, -17.84) | |
| 4:187000010 | COSM3702566 | D>A | A:153 | (-67.34, 30.96, -13.44) |
| 4:187000024 | G>S | A:158 | (-78.67, 25.24, -10.01) | |
| 4:187000040 | rs145104245 | K>T | A:163 | (-82.36, 32.51, -20.49) |
| 4:187000061 | L>P | A:170 | (-71.71, 39.72, -22.88) | |
| 4:187000076 | E>A | A:175 | (-63.67, 31.78, -20.84) | |
| 4:187000078 | L>I | A:176 | (-69.60, 30.45, -20.32) | |
| 4:187000106 | rs35140061 | A>V | A:185 | (-81.08, 21.89, -22.37) |
| 4:187000123 | L>M | A:191 | (-77.43, 29.96, -26.23) | |
| 4:187000127 | D>G | A:192 | (-79.60, 34.01, -29.19) | |
| 4:187000130 | I>N | A:193 | (-77.59, 36.09, -25.77) | |
| 4:187000149 | L>F | A:199 | (-67.70, 31.94, -26.89) | |
| 4:187000165 | S>T | A:205 | (-68.96, 19.91, -17.31) | |
| 4:187000169 | S>L | A:206 | (-71.05, 17.96, -14.56) | |
| 4:187000183 | E>K | A:211 | (-82.77, 17.98, -26.34) | |
| 4:187003493 | H>R | A:218 | (-75.06, 27.45, -35.97) | |
| 4:187003505 | COSM1267915 | R>K | A:222 | (-66.73, 32.87, -34.30) |
| 4:187003511 | F>S | A:224 | (-63.58, 28.97, -31.29) | |
| 4:187003513 | G>S | A:225 | (-65.03, 25.36, -27.25) | |
| 4:187003527 | N>K | A:229 | (-66.39, 16.64, -19.62) | |
| 4:187003536 | Q>H | A:232 | (-75.08, 10.52, -18.76) | |
| 4:187003537 | L>V | A:233 | (-74.14, 11.83, -24.25) | |
| 4:187003544 | P>R | A:235 | (-73.56, 6.63, -29.07) | |
| 4:187003568 | L>W | A:243 | (-75.12, 16.26, -36.89) | |
| 4:187003582 | T>A | A:248 | (-69.25, 25.17, -36.74) | |
| 4:187003592 | rs539192081 COSM209101 |
R>Q | A:251 | (-60.17, 24.62, -34.10) |
| 4:187003613 | S>I | A:258 | (-69.66, 10.24, -22.35) | |
| 4:187003627 | T>A | A:263 | (-67.45, 4.06, -32.14) | |
| 4:187003663 | N>D | A:275 | (-61.78, 23.03, -39.27) | |
| 4:187003675 | rs375673282 | L>F | A:279 | (-61.03, 14.69, -29.87) |
| 4:187003678 | rs112077022 | D>N | A:280 | (-60.97, 14.23, -24.97) |
| 4:187003684 | S>P | A:282 | (-61.27, 10.15, -22.03) | |
| 4:187003688 | Y>C | A:283 | (-61.12, 8.65, -18.15) | |
| 4:187003691 | rs5743316 | N>I | A:284 | (-65.71, 7.06, -22.55) |
| 4:187003700 | N>S | A:287 | (-66.02, -1.47, -25.49) | |
| 4:187003714 | rs371800977 | D>N | A:292 | (-64.13, 4.40, -41.17) |
| 4:187003729 | rs35311343 | L>V | A:297 | (-61.92, 14.39, -37.82) |
| 4:187003759 | rs5743317 | Y>D | A:307 | (-56.88, 6.20, -18.48) |
| 4:187003769 | I>T | A:310 | (-60.25, -1.00, -26.55) | |
| 4:187003779 | L>F | A:313 | (-57.77, -1.89, -32.84) | |
| 4:187003792 | L>M | A:318 | (-57.32, 4.56, -36.44) | |
| 4:187003808 | N>S | A:323 | (-53.37, 15.84, -40.22) | |
| 4:187003831 | R>W | A:331 | (-53.96, 1.55, -18.37) | |
| 4:187003850 | S>N | A:337 | (-59.19, -12.19, -18.07) | |
| 4:187003852 | rs138548725 | I>V | A:338 | (-56.18, -14.01, -15.89) |
| 4:187003855 | S>A | A:339 | (-59.38, -16.86, -17.20) | |
| 4:187003856 | COSM209102 | S>Y | A:339 | (-59.38, -16.86, -17.20) |
| 4:187003886 | F>S | A:349 | (-50.53, -2.77, -41.55) | |
| 4:187003898 | W>S | A:353 | (-54.63, 4.41, -42.02) | |
| 4:187003919 | L>P | A:360 | (-47.38, 7.08, -29.98) | |
| 4:187003921 | N>Y | A:361 | (-48.58, 7.53, -25.02) | |
| 4:187003930 | D>N | A:364 | (-49.62, 1.73, -18.80) | |
| 4:187003936 | D>Y | A:366 | (-52.27, -5.81, -21.08) | |
| 4:187003940 | I>T | A:367 | (-50.27, -5.11, -25.92) | |
| 4:187003945 | G>R | A:369 | (-47.10, -7.72, -28.70) | |
| 4:187003957 | rs578216202 | N>H | A:373 | (-46.48, -4.98, -39.92) |
| 4:187003979 | N>I | A:380 | (-43.53, 11.91, -39.14) | |
| 4:187003986 | K>N | A:382 | (-40.08, 12.43, -34.07) | |
| 4:187003988 | Y>F | A:383 | (-42.24, 9.88, -27.51) | |
| 4:187003992 | L>F | A:384 | (-42.67, 5.16, -29.04) | |
| 4:187004012 | T>I | A:391 | (-47.98, -8.74, -21.17) | |
| 4:187004021 | rs141634515 | R>Q | A:394 | (-40.27, -12.35, -20.59) |
| 4:187004060 | rs372290492 | S>F | A:407 | (-39.53, 5.64, -38.28) |
| 4:187004088 | K>N | A:416 | (-42.66, -0.51, -16.25) | |
| 4:187004101 | K>E | A:421 | (-32.46, -11.97, -23.68) | |
| 4:187004125 | W>G | A:429 | (-34.70, -2.59, -38.31) | |
| 4:187004135 | rs145303119 | H>R | A:432 | (-32.50, 8.11, -37.28) |
| 4:187004141 | rs377028149 | E>G | A:434 | (-31.43, 10.71, -30.14) |
| 4:187004143 | V>I | A:435 | (-33.38, 8.57, -26.03) | |
| 4:187004146 | L>F | A:436 | (-32.85, 3.60, -25.28) | |
| 4:187004158 | L>F | A:440 | (-37.73, -0.06, -14.56) | |
| 4:187004161 | N>D | A:441 | (-36.73, -3.94, -17.10) | |
| 4:187004180 | L>H | A:447 | (-23.51, -6.33, -22.81) | |
| 4:187004192 | rs200494519 | E>V | A:451 | (-26.61, -5.77, -27.89) |
| 4:187004194 | W>R | A:452 | (-26.19, -1.33, -27.38) | |
| 4:187004218 | rs144550375 | E>K | A:460 | (-29.84, 9.39, -23.23) |
| 4:187004221 | COSM3428392 | I>V | A:461 | (-28.38, 4.33, -22.89) |
| 4:187004258 | R>K | A:473 | (-12.24, -5.15, -25.12) | |
| 4:187004264 | S>C | A:475 | (-19.82, -3.70, -24.49) | |
| 4:187004278 | P>S | A:480 | (-18.92, 5.92, -30.03) | |
| 4:187004283 | S>R | A:481 | (-21.92, 8.70, -29.91) | |
| 4:187004291 | R>Q | A:484 | (-26.59, 12.07, -20.99) | |
| 4:187004303 | R>Q | A:488 | (-29.22, 4.17, -9.92) | |
| 4:187004307 | R>S | A:489 | (-30.90, -1.39, -8.92) | |
| 4:187004311 | A>T | A:491 | (-24.93, -5.53, -11.33) | |
| 4:187004322 | N>K | A:494 | (-16.13, -8.04, -15.77) | |
| 4:187004329 | rs369886993 | S>G | A:497 | (-11.82, -4.68, -16.74) |
| 4:187004335 | P>S | A:499 | (-9.41, -3.51, -20.92) | |
| 4:187004338 | S>P | A:500 | (-12.42, -0.15, -19.90) | |
| 4:187004356 | COSM1053881 | R>C | A:506 | (-13.01, 9.03, -26.17) |
| 4:187004357 | rs199658443 | R>H | A:506 | (-13.01, 9.03, -26.17) |
| 4:187004366 | T>S | A:509 | (-20.94, 13.71, -20.35) | |
| 4:187004368 | rs202066722 | I>V | A:510 | (-23.66, 11.99, -17.75) |
| 4:187004374 | D>H | A:512 | (-25.32, 6.56, -12.98) | |
| 4:187004384 | N>T | A:515 | (-27.35, 2.08, -6.09) | |
| 4:187004386 | N>D | A:516 | (-24.19, -1.01, -8.40) | |
| 4:187004401 | I>V | A:521 | (-12.73, -0.07, -9.46) | |
| 4:187004405 | N>S | A:522 | (-9.40, -1.18, -12.05) | |
| 4:187004410 | D>N | A:524 | (-7.88, 1.58, -16.47) | |
| 4:187004411 | rs373400665 | D>V | A:524 | (-7.88, 1.58, -16.47) |
| 4:187004425 | rs201222071 COSM3130998 |
L>F | A:529 | (-14.15, 8.91, -20.02) |
| 4:187004426 | L>P | A:529 | (-14.15, 8.91, -20.02) | |
| 4:187004428 | E>K | A:530 | (-10.82, 12.40, -21.58) | |
| 4:187004435 | L>P | A:532 | (-16.84, 12.70, -17.66) | |
| 4:187004440 | I>V | A:534 | (-21.92, 14.36, -14.42) | |
| 4:187004453 | Q>P | A:538 | (-23.94, 7.38, -5.55) | |
| 4:187004456 | H>R | A:539 | (-25.29, 4.24, -2.24) | |
| 4:187004485 | A>T | A:549 | (-3.70, -1.39, 2.97) | |
| 4:187004486 | A>V | A:549 | (-3.70, -1.39, 2.97) | |
| 4:187004500 | rs121434431 | P>S | A:554 | (-4.22, 3.88, -3.49) |
| 4:187004507 | Y>C | A:556 | (-4.78, 7.20, -7.14) | |
| 4:187004524 | rs149184129 | S>P | A:562 | (-10.15, 17.52, -17.15) |
| 4:187004533 | H>Y | A:565 | (-17.94, 19.97, -14.25) | |
| 4:187004539 | L>V | A:567 | (-17.69, 13.78, -7.77) | |
| 4:187004555 | N>S | A:572 | (-18.71, 4.67, -0.60) | |
| 4:187004557 | G>S | A:573 | (-17.08, 4.01, 3.65) | |
| 4:187004566 | COSM3940835 | E>K | A:576 | (-8.49, 6.11, 4.47) |
| 4:187004571 | I>M | A:577 | (-9.23, 10.69, 1.44) | |
| 4:187004575 | V>F | A:579 | (-3.25, 13.42, -1.21) | |
| 4:187004614 | rs184426724 | D>N | A:592 | (-20.94, 15.06, -3.31) |
| 4:187004623 | L>V | A:595 | (-23.41, 9.64, 3.79) | |
| 4:187004713 | V>I | A:625 | (-11.73, 22.12, 10.57) | |
| 4:187004721 | rs372944756 | K>N | A:627 | (-5.09, 26.71, 7.15) |
| 4:187004755 | E>K | A:639 | (-23.39, 25.01, -0.69) | |
| 4:187004765 | M>T | A:642 | (-20.25, 20.16, 7.29) | |
| 4:187004768 | rs150315296 | R>H | A:643 | (-26.87, 18.71, 7.28) |
| 4:187004791 | C>S | A:651 | (-8.65, 26.31, 19.87) | |
| 4:187004839 | rs376729108 | N>H | A:667 | (-25.45, 29.75, 1.84) |
| 4:187004866 | L>F | A:676 | (-24.24, 20.65, 17.31) | |
| 4:187004899 | P>A | A:687 | (-23.74, 25.91, 18.90) | |
| 4:187004927 | C>S | A:696 | (-6.99, 31.26, 20.35) |
[+] COSMIC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 4:186998061 | COSM1724344 | Q>H | A:96 | (-71.35, 53.63, -7.89) |
| 4:186999997 | COSM1159593 | L>V | A:149 | (-67.18, 40.09, -18.87) |
| 4:187003516 | COSM1053877 | L>I | A:226 | (-67.73, 21.97, -26.53) |
| 4:187003942 | COSM1695302 | P>S | A:368 | (-49.79, -9.22, -26.71) |
| 4:187004074 | COSM149771 | L>F | A:412 | (-37.88, 3.86, -27.39) |
| 4:187004218 | COSM1229396 | E>K | A:460 | (-29.84, 9.39, -23.23) |
| 4:187004356 | COSM1053881 | R>C | A:506 | (-13.01, 9.03, -26.17) |
| 4:187004578 | COSM1753672 | E>Q | A:580 | (-2.52, 13.58, -5.02) |