General Structure Information
| PDB ID | 1gum |
| HGNC Gene Label(s) | GSTA4 |
| Structure Name | human glutathione transferase a4-4 without ligands |
| Resolution | 3.0Å |
| Reference | AUTH C.M.BRUNS,I.HUBATSCH,M.RIDDERSTROM,B.MANNERVIK,AUTH 2 J.A.TAINERTITL HUMAN GLUTATHIONE TRANSFERASE A4-4 CRYSTALTITL 2 STRUCTURES AND MUTAGENESIS REVEAL THE BASIS OFTITL 3 HIGH CATALYTIC EFFICIENCY WITH TOXIC LIPIDTITL 4 PEROXIDATION PRODUCTSREF J.MOL.BIOL. V. 288 427 1999REFN ISSN 0022-2836PMID 10329152DOI 10.1006/JMBI.1999.2697 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 217 |
| Number Of SNVs | 60 |
| Number Of Permutations | 7309 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.273 |
| p-value | 0.7 |
COSMIC
| Number Of Residues | 217 |
| Number Of SNVs | 4 |
| Number Of Permutations | 44 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.167 |
| p-value | 0.837 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 60 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | -0.207 |
| p-value | 0.587 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
