2BP1.C | AKR7A2

General Structure Information

PDB ID	2bp1
HGNC Gene Label(s)	AKR7A2
Structure Name	structure of the aflatoxin aldehyde reductase in complex with nadph
Resolution	2.4Å
Reference	AUTH J.E.DEBRECZENI,P.LUKACIK,K.KAVANAGH,E.DUBININA,J.BRAY,AUTH 2 S.COLEBROOK,A.HARONITI,A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,AUTH 3 F.VON DELFT,O.GILEADI,U.OPPERMANNTITL STRUCTURE OF THE AFLATOXIN ALDEHYDE REDUCTASE IN COMPLEXTITL 2 WITH NADPHREF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	320
Number Of SNVs	98
Number Of Permutations	14949
Optimal Distance Threshold	5.0
K Statistic	0.005
p-value	0.918

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
1:19638504		A>S	C:40	(-34.62, 11.78, -43.98)
1:19638473		R>P	C:50	(-52.11, -0.18, -31.73)
1:19638440		V>A	C:61	(-36.56, -2.38, -37.26)
1:19638437		R>H	C:62	(-35.10, -7.03, -39.60)
1:19638434	rs572987774	A>V	C:63	(-36.28, -3.15, -43.10)
1:19638435	rs182169477	A>T	C:63	(-36.28, -3.15, -43.10)
1:19638422	rs373072611	R>L	C:67	(-34.11, 0.14, -47.75)
1:19638420	rs554728072	G>S	C:68	(-29.73, 2.94, -44.04)
1:19638404		D>A	C:73	(-40.39, 8.20, -33.21)
1:19638384		D>N	C:80	(-50.22, 1.84, -23.02)
1:19638381		G>R	C:81	(-45.34, 1.17, -23.43)
1:19638362		L>Q	C:87	(-38.00, -0.82, -29.50)
1:19638353	rs370144404	L>Q	C:90	(-35.01, -5.44, -30.51)
1:19638348		L>F	C:92	(-30.67, -2.41, -31.01)
1:19638344		G>E	C:93	(-27.94, -0.80, -27.78)
1:19635133		K>T	C:102	(-29.52, 6.96, -33.11)
1:19635130		I>T	C:103	(-33.96, 6.31, -29.70)
1:19635091		K>R	C:116	(-45.34, 20.02, -13.49)
1:19635076		R>Q	C:121	(-36.55, 13.10, -13.41)
1:19635077	rs146046785	R>W	C:121	(-36.55, 13.10, -13.41)
1:19635073		S>C	C:122	(-41.02, 9.83, -14.37)
1:19635063		E>D	C:125	(-36.21, 7.94, -15.04)
1:19635050		R>G	C:130	(-40.77, 1.47, -20.98)
1:19635037	COSM3863955	P>L	C:134	(-28.36, 4.87, -20.83)
1:19635032	rs6670759	V>M	C:136	(-32.28, 9.16, -25.28)
1:19635025		L>P	C:138	(-34.42, 13.05, -29.51)
1:19635013		H>R	C:142	(-45.82, 14.30, -27.47)
1:19635010	rs548236491	A>V	C:143	(-47.25, 18.50, -26.03)
1:19635011	rs1043657	A>T	C:143	(-47.25, 18.50, -26.03)
1:19634999		G>S	C:147	(-50.50, 24.73, -16.74)
1:19634995	rs371315371	T>I	C:148	(-47.01, 24.13, -16.54)
1:19634993		P>A	C:149	(-44.97, 27.22, -16.18)
1:19634989		V>A	C:150	(-42.26, 26.66, -20.26)
1:19634983		E>V	C:152	(-41.54, 24.87, -14.17)
1:19634980	COSM3943237	T>M	C:153	(-40.62, 22.16, -18.32)
1:19634981	rs571799954	T>A	C:153	(-40.62, 22.16, -18.32)
1:19634975		H>Y	C:155	(-34.52, 24.24, -14.72)
1:19634968		C>Y	C:157	(-34.90, 19.44, -19.55)
1:19634964	rs859208	Q>H	C:158	(-30.51, 21.93, -18.37)
1:19634962	rs199568440	R>Q	C:159	(-30.47, 18.52, -13.52)
1:19634963	rs150666132	R>W	C:159	(-30.47, 18.52, -13.52)
1:19634959		L>P	C:160	(-32.84, 15.47, -17.16)
1:19634957		H>Y	C:161	(-28.41, 17.49, -21.19)
1:19634951		E>Q	C:163	(-28.59, 13.96, -14.96)
1:19634752		K>R	C:165	(-30.94, 10.95, -18.35)
1:19634746	rs143442378	V>A	C:167	(-28.19, 14.17, -26.52)
1:19634747	rs111682618	V>M	C:167	(-28.19, 14.17, -26.52)
1:19634744		E>Q	C:168	(-30.67, 16.38, -29.50)
1:19634737	rs199820959	G>D	C:170	(-37.63, 18.55, -28.38)
1:19634695		T>N	C:184	(-35.55, 33.35, -25.95)
1:19634693	rs201886268	L>F	C:185	(-36.48, 31.37, -21.84)
1:19634689		C>Y	C:186	(-32.91, 28.70, -23.22)
1:19634680		N>S	C:189	(-31.56, 30.86, -18.67)
1:19634672		I>V	C:192	(-30.43, 22.56, -24.00)
1:19634666	rs144757440	P>S	C:194	(-34.56, 23.32, -28.77)
1:19634659		V>E	C:196	(-35.90, 18.65, -33.24)
1:19634652	rs549972531	Q>H	C:198	(-42.28, 15.62, -34.27)
1:19633904	rs2231200	G>S	C:199	(-44.75, 17.76, -37.31)
1:19633894		N>S	C:202	(-49.39, 16.42, -45.50)
1:19633885	rs368016830	T>I	C:205	(-51.30, 19.31, -44.21)
1:19633886		T>A	C:205	(-51.30, 19.31, -44.21)
1:19633882	rs146583457	R>Q	C:206	(-48.90, 22.50, -47.78)
1:19633883	rs200402102	R>W	C:206	(-48.90, 22.50, -47.78)
1:19633877	rs376273268	V>M	C:208	(-46.02, 24.27, -40.90)
1:19633870		T>M	C:210	(-46.69, 30.36, -42.88)
1:19633859		P>S	C:214	(-39.90, 30.58, -40.73)
1:19633828	rs573103736	Y>C	C:224	(-37.51, 15.04, -37.60)
1:19633810		A>V	C:230	(-53.01, 11.60, -43.61)
1:19633811	rs115276777	A>S	C:230	(-53.01, 11.60, -43.61)
1:19633581	rs377621683	G>C	C:236	(-56.93, 6.09, -51.53)
1:19633554	rs548864318	G>R	C:245	(-71.03, 2.32, -43.30)
1:19633535		R>H	C:251	(-54.84, 5.98, -37.91)
1:19633536	rs369846651	R>C	C:251	(-54.84, 5.98, -37.91)
1:19633505		Y>C	C:261	(-56.17, 10.80, -36.80)
1:19633497	rs141023615	R>C	C:264	(-56.09, 15.43, -37.48)
1:19632640		F>V	C:265	(-56.67, 14.41, -41.79)
1:19632628		H>Y	C:269	(-63.55, 20.07, -50.00)
1:19632612		I>T	C:274	(-57.30, 12.59, -52.95)
1:19632596		K>N	C:279	(-57.95, 13.36, -62.90)
1:19632594		A>G	C:280	(-52.94, 13.87, -62.58)
1:19632588		Q>R	C:282	(-54.94, 8.72, -64.28)
1:19632583	COSM4026482	A>T	C:284	(-49.03, 12.35, -66.57)
1:19632574	rs368076399	A>T	C:287	(-49.94, 3.18, -67.62)
1:19632568		A>T	C:289	(-48.97, 5.45, -62.84)
1:19632564		P>R	C:290	(-47.79, 6.38, -59.75)
1:19632552	rs79772073	S>L	C:294	(-45.81, 7.03, -54.20)
1:19632540	rs199970984 COSM4026481	R>Q	C:298	(-42.42, 10.45, -55.41)
1:19632541	rs371998843 COSM133921	R>W	C:298	(-42.42, 10.45, -55.41)
1:19632534		M>R	C:300	(-42.82, 14.91, -48.17)
1:19632532		Y>H	C:301	(-38.77, 12.08, -48.95)
1:19632528		H>R	C:302	(-38.24, 14.68, -54.17)
1:19630877	rs578096792	A>T	C:309	(-29.40, 20.71, -45.65)
1:19630873		H>R	C:310	(-31.78, 22.67, -43.29)
1:19630874	rs147751116	H>Y	C:310	(-31.78, 22.67, -43.29)
1:19630864	rs2231206	A>V	C:313	(-37.41, 14.34, -41.80)
1:19630865	rs148427383	A>T	C:313	(-37.41, 14.34, -41.80)
1:19630856	rs555329794	L>V	C:316	(-42.10, 6.50, -42.44)
1:19630846		S>C	C:319	(-50.02, -1.18, -39.66)
1:19630829		E>Q	C:325	(-42.13, -1.84, -47.89)
1:19630822		N>I	C:327	(-44.04, 3.32, -47.58)
1:19630818		L>F	C:328	(-39.08, 1.97, -47.52)
1:19630789	rs576464259	P>L	C:338	(-44.42, 19.08, -63.18)
1:19630781		V>M	C:341	(-46.39, 19.22, -58.13)
1:19630775		A>T	C:343	(-52.12, 19.05, -58.27)
1:19630763		A>P	C:347	(-55.25, 20.16, -53.27)
1:19630755		H>Q	C:349	(-54.78, 25.96, -52.73)
1:19630752		L>F	C:350	(-59.53, 22.30, -52.35)
1:19630750	COSM3480716	V>A	C:351	(-57.98, 21.68, -47.82)
1:19630751		V>F	C:351	(-57.98, 21.68, -47.82)
1:19630744		H>R	C:353	(-61.00, 25.87, -45.86)
1:19630735		P>L	C:356	(-55.40, 20.84, -39.41)
1:19630736	rs561191192	P>A	C:356	(-55.40, 20.84, -39.41)
1:19630723		R>H	C:360	(-51.74, 19.82, -29.85)
1:19630724	rs149142830	R>C	C:360	(-51.74, 19.82, -29.85)