General Structure Information
| PDB ID | 2lkn |
| HGNC Gene Label(s) | AIP |
| Structure Name | solution structure of the ppiase domain of human aryl-hydrocarbon receptor-interacting protein (aip) |
| Resolution | -1.0Å |
| Reference | AUTH M.LINNERT,Y.J.LIN,A.MANNS,K.HAUPT,A.K.PASCHKE,G.FISCHER,AUTH 2 M.WEIWAD,C.LUECKETITL THE FKBP-TYPE DOMAIN OF THE HUMAN ARYL HYDROCARBONTITL 2 RECEPTOR-INTERACTING PROTEIN REVEALS AN UNUSUAL HSP90TITL 3 INTERACTION.REF BIOCHEMISTRY V. 52 2097 2013REFN ISSN 0006-2960PMID 23418784DOI 10.1021/BI301649M |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 165 |
| Number Of SNVs | 47 |
| Number Of Permutations | 5415 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.06 |
| p-value | 0.909 |
ClinVar
| Number Of Residues | 165 |
| Number Of SNVs | 4 |
| Number Of Permutations | 291 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.167 |
| p-value | 0.629 |
COSMIC
| Number Of Residues | 165 |
| Number Of SNVs | 3 |
| Number Of Permutations | 7 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.333 |
| p-value | 0.217 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 47 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.146 |
| p-value | 0.544 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 47 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.558 |
| p-value | 0.058 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
