1WZV.B | UBE2L6

General Structure Information

PDB ID	1wzv
HGNC Gene Label(s)	UBE2L6
Structure Name	crystal structure of ubch8
Resolution	2.1Å
Reference	AUTH T.MIZUSHIMA,M.SUZUKI,N.TESHIMA,T.YAMANE,S.MURATA,AUTH 2 K.TANAKATITL CRYSTAL STRUCTURE OF UBCH8REF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	150
Number Of SNVs	41
Number Of Permutations	4550
Optimal Distance Threshold	10.0
K Statistic	0.096
p-value	0.786

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
11:57335078		A>P	B:2	(66.49, 16.93, 74.31)
11:57335072		M>V	B:4	(67.18, 13.10, 69.93)
11:57327902		L>V	B:10	(55.69, 13.87, 69.60)
11:57327896		D>Y	B:12	(55.54, 7.24, 70.87)
11:57327893	rs538346823	L>V	B:13	(51.94, 10.65, 72.56)
11:57327884	rs143103984	K>E	B:16	(49.36, 4.54, 70.30)
11:57327874	rs549126873	P>L	B:19	(41.44, 9.75, 75.06)
11:57327865		R>Q	B:22	(41.83, 14.83, 71.00)
11:57327860		L>M	B:24	(50.06, 16.34, 70.05)
11:57327841		N>S	B:30	(60.78, 24.66, 68.86)
11:57327842		N>D	B:30	(60.78, 24.66, 68.86)
11:57327824	rs35921478	A>T	B:36	(47.47, 20.39, 73.10)
11:57322092		Q>R	B:42	(34.27, 16.69, 85.88)
11:57322090		P>T	B:43	(31.15, 17.87, 84.69)
11:57322064		N>K	B:51	(45.56, 24.90, 74.15)
11:57322059		R>H	B:53	(53.63, 26.50, 75.57)
11:57322047	rs372087046	P>L	B:57	(63.93, 22.15, 79.24)
11:57322039		Y>N	B:60	(63.54, 16.56, 78.90)
11:57322035		P>L	B:61	(65.71, 14.48, 80.69)
11:57322020	rs571633324	M>T	B:66	(57.66, 24.09, 81.51)
11:57321992		H>Q	B:75	(39.91, 24.42, 87.95)
11:57321987		N>S	B:77	(43.55, 23.56, 90.77)
11:57321984		V>A	B:78	(44.10, 26.72, 86.95)
11:57321985		V>M	B:78	(44.10, 26.72, 86.95)
11:57321979		E>K	B:80	(43.43, 34.27, 86.39)
11:57321972		G>V	B:82	(47.51, 28.74, 83.32)
11:57321951	rs140267878	I>T	B:89	(56.38, 18.82, 86.81)
11:57321924		T>S	B:98	(59.25, 10.99, 84.17)
11:57321915		C>Y	B:101	(52.82, 10.34, 79.23)
11:57319967	rs151180286	N>S	B:108	(43.36, 14.29, 82.95)
11:57319968		N>H	B:108	(43.36, 14.29, 82.95)
11:57319949	rs544348600 COSM396387	P>L	B:114	(39.14, 19.18, 91.78)
11:57319950		P>S	B:114	(39.14, 19.18, 91.78)
11:57319942		I>M	B:116	(39.89, 22.00, 98.06)
11:57319928		R>L	B:121	(41.25, 30.85, 91.06)
11:57319929	rs199745337	R>W	B:121	(41.25, 30.85, 91.06)
11:57319920		L>V	B:124	(37.18, 29.31, 92.54)
11:57319917		A>T	B:125	(37.67, 26.61, 96.39)
11:57319914		D>N	B:126	(36.19, 28.75, 99.22)
11:57319897		N>K	B:131	(27.23, 26.18, 96.21)
11:57319899		N>H	B:131	(27.23, 26.18, 96.21)
11:57319872		E>K	B:140	(28.10, 25.73, 82.23)
11:57319866		F>V	B:142	(34.90, 31.10, 82.03)
11:57319862		T>I	B:143	(33.55, 26.54, 79.64)
11:57319860	rs368600663	L>F	B:144	(30.10, 27.60, 77.14)
11:57319844		D>V	B:149	(35.12, 24.27, 69.61)
11:57319842		R>W	B:150	(35.15, 18.57, 73.43)