General Structure Information
| PDB ID | 2a66 |
| HGNC Gene Label(s) | NR5A2 |
| Structure Name | human liver receptor homologue dna-binding domain (hlrh-1 dbd) in complex with dsdna from the hcyp7a1 promoter |
| Resolution | 2.2Å |
| Reference | AUTH I.H.SOLOMON,J.M.HAGER,R.SAFI,D.P.MCDONNELL,AUTH 2 M.R.REDINBO,E.A.ORTLUNDTITL CRYSTAL STRUCTURE OF THE HUMAN LRH-1 DBD-DNATITL 2 COMPLEX REVEALS FTZ-F1 DOMAIN POSITIONING ISTITL 3 REQUIRED FOR RECEPTOR ACTIVITY.REF J.MOL.BIOL. V. 354 1091 2005REFN ISSN 0022-2836PMID 16289203DOI 10.1016/J.JMB.2005.10.009 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 95 |
| Number Of SNVs | 10 |
| Number Of Permutations | 923 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.0 |
| p-value | 0.952 |
COSMIC
| Number Of Residues | 95 |
| Number Of SNVs | 3 |
| Number Of Permutations | 42 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | 0.333 |
| p-value | 0.132 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 10 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | -0.422 |
| p-value | 0.155 |