4L3I.B | PRC1 – ASTRID

4L3I.B | PRC1

General Structure Information

PDB ID	4l3i
HGNC Gene Label(s)	PRC1
Structure Name	structure of the microtubule associated protein prc1 (protein regulator of cytokinesis 1)
Resolution	3.6Å
Reference	AUTH R.SUBRAMANIAN,S.C.TI,L.TAN,S.A.DARST,T.M.KAPOORTITL MARKING AND MEASURING SINGLE MICROTUBULES BY PRC1 ANDTITL 2 KINESIN-4.REF CELL(CAMBRIDGE,MASS.) V. 154 377 2013REFN ISSN 0092-8674PMID 23870126DOI 10.1016/J.CELL.2013.06.021

Variant Set Distributions

ExAC Variants

Number Of Residues	430
Number Of SNVs	115
Number Of Permutations	63315
Optimal Distance Threshold	6.0
K Statistic	0.007
p-value	0.1

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
15:91537638		S>G	B:4	(-16.38, -133.88, -9.59)
15:91528054		E>K	B:5	(-16.00, -135.75, -6.60)
15:91528044	rs570196720 COSM1708562	A>V	B:8	(-16.84, -139.80, -8.91)
15:91528038		E>V	B:10	(-22.33, -140.91, -9.11)
15:91528006	rs149781966	H>D	B:21	(-26.87, -157.59, -11.28)
15:91527999	rs139670079	R>Q	B:23	(-22.04, -161.83, -10.30)
15:91528000	rs374649597	R>W	B:23	(-22.04, -161.83, -10.30)
15:91527960		R>Q	B:36	(-17.47, -166.47, -13.13)
15:91527946		E>Q	B:41	(-10.43, -159.29, -17.92)
15:91527933	rs150693304	K>R	B:45	(-8.86, -153.97, -19.98)
15:91527934		K>Q	B:45	(-8.86, -153.97, -19.98)
15:91527366		L>R	B:50	(-10.85, -145.18, -21.69)
15:91527335		S>R	B:60	(-0.37, -133.74, -23.48)
15:91527309		I>T	B:69	(3.68, -120.65, -20.84)
15:91527304		V>I	B:71	(7.26, -119.86, -26.49)
15:91527282	COSM4057980	T>I	B:78	(11.62, -110.45, -27.49)
15:91527283		T>A	B:78	(11.62, -110.45, -27.49)
15:91527271		E>K	B:82	(10.99, -104.14, -28.57)
15:91527262	rs150916803	V>I	B:85	(10.01, -102.37, -21.35)
15:91527253		F>L	B:88	(1.04, -107.12, -16.55)
15:91525207		E>G	B:91	(-1.44, -111.03, -8.42)
15:91525193		I>V	B:96	(-1.26, -123.01, -15.61)
15:91525168	rs558894857	R>H	B:104	(-2.79, -117.03, -25.98)
15:91525169	COSM246761	R>C	B:104	(-2.79, -117.03, -25.98)
15:91525160	rs200166514	V>L	B:107	(1.82, -111.70, -27.82)
15:91525147	rs142124129	R>Q	B:111	(2.70, -111.27, -32.71)
15:91525138		K>T	B:114	(5.96, -105.75, -34.76)
15:91525131		E>D	B:116	(1.74, -101.00, -36.79)
15:91525124		Q>K	B:119	(3.62, -99.91, -41.41)
15:91525121		E>Q	B:120	(3.99, -96.60, -40.21)
15:91525109		L>F	B:124	(6.40, -91.84, -42.67)
15:91525103		E>K	B:126	(5.37, -94.12, -49.36)
15:91525098		Q>H	B:127	(4.39, -89.72, -46.73)
15:91525093	rs113935358	Q>R	B:129	(9.91, -89.85, -50.97)
15:91525085		C>R	B:132	(11.90, -85.53, -51.16)
15:91525063		H>R	B:139	(15.70, -89.08, -48.05)
15:91525064		H>Y	B:139	(15.70, -89.08, -48.05)
15:91525060		Y>C	B:140	(15.29, -88.87, -41.49)
15:91525054		I>T	B:142	(17.71, -93.90, -41.32)
15:91525048	rs142416384	S>T	B:144	(16.45, -98.34, -40.36)
15:91525049		S>C	B:144	(16.45, -98.34, -40.36)
15:91525042		S>L	B:146	(13.78, -102.51, -38.67)
15:91525040		V>L	B:147	(12.90, -101.10, -35.26)
15:91525033		S>N	B:149	(11.35, -95.62, -31.56)
15:91524982	rs137858168	T>R	B:166	(8.79, -76.08, -46.85)
15:91524889		R>H	B:171	(1.62, -74.04, -54.32)
15:91524890	rs573547983 COSM1375502	R>C	B:171	(1.62, -74.04, -54.32)
15:91524882	rs549719996 COSM296620	E>D	B:173	(7.39, -67.93, -53.17)
15:91524879		F>L	B:174	(4.76, -71.41, -58.55)
15:91524857	rs147013874	I>L	B:182	(1.34, -64.35, -66.36)
15:91524850		C>Y	B:184	(5.09, -59.59, -67.94)
15:91524841	rs7172758	A>E	B:187	(2.80, -55.45, -71.44)
15:91524834		D>E	B:189	(3.51, -60.56, -76.53)
15:91524831		H>Q	B:190	(7.11, -64.29, -75.27)
15:91524829		T>N	B:191	(4.82, -66.51, -76.39)
15:91524827	rs527463974	P>S	B:192	(5.99, -68.92, -74.08)
15:91524821		T>P	B:194	(10.17, -72.25, -73.61)
15:91524800		V>L	B:201	(2.40, -71.24, -68.20)
15:91524784		D>G	B:206	(1.30, -79.86, -59.92)
15:91524756		I>M	B:215	(13.77, -71.36, -58.19)
15:91524757		I>T	B:215	(13.77, -71.36, -58.19)
15:91524754		A>G	B:216	(16.74, -69.94, -59.35)
15:91524745		Q>R	B:219	(13.91, -65.61, -58.75)
15:91524737		L>I	B:222	(11.29, -62.32, -62.97)
15:91524733		R>Q	B:223	(17.10, -61.02, -62.18)
15:91524734	rs138904992	R>W	B:223	(17.10, -61.02, -62.18)
15:91524243		Q>H	B:231	(15.56, -52.36, -71.50)
15:91524245		Q>E	B:231	(15.56, -52.36, -71.50)
15:91524235	rs533610719	A>V	B:234	(13.30, -46.17, -71.18)
15:91524217		R>H	B:240	(7.24, -40.73, -73.61)
15:91524218		R>C	B:240	(7.24, -40.73, -73.61)
15:91524214		T>I	B:241	(11.70, -36.52, -73.97)
15:91524210		Q>H	B:242	(12.80, -36.64, -79.27)
15:91524208	rs547936544	I>T	B:243	(7.85, -35.81, -78.73)
15:91524209	rs149838434	I>L	B:243	(7.85, -35.81, -78.73)
15:91524205	COSM4057978	R>Q	B:244	(7.71, -34.06, -73.76)
15:91524196		W>S	B:247	(5.21, -31.21, -77.95)
15:91524194		D>N	B:248	(9.36, -26.81, -76.52)
15:91524160		A>V	B:259	(-4.30, -36.47, -78.36)
15:91524134		K>E	B:268	(3.19, -52.77, -76.56)
15:91524124		V>A	B:271	(3.38, -47.25, -78.06)
15:91524121	rs149143720	R>Q	B:272	(8.88, -48.83, -79.26)
15:91524115		A>V	B:274	(3.72, -44.78, -83.03)
15:91523615		Q>R	B:276	(9.87, -43.91, -84.64)
15:91523612		L>S	B:277	(6.14, -42.31, -86.63)
15:91523598		L>V	B:282	(7.31, -34.09, -86.15)
15:91523586		K>E	B:286	(12.01, -29.05, -88.62)
15:91523579		Q>R	B:288	(9.42, -29.72, -95.80)
15:91523576		N>S	B:289	(8.56, -25.78, -92.31)
15:91523565		V>M	B:293	(11.84, -20.34, -94.96)
15:91523549	rs373993897	R>Q	B:298	(15.68, -17.12, -102.28)
15:91523495		Q>R	B:316	(28.51, -17.76, -108.21)
15:91523483	COSM1708561	P>L	B:320	(25.17, -22.20, -100.56)
15:91523477		C>Y	B:322	(22.25, -26.57, -104.68)
15:91523478	rs201583559	C>S	B:322	(22.25, -26.57, -104.68)
15:91522521	rs377034634	D>G	B:325	(20.10, -29.17, -96.99)
15:91522519		Y>H	B:326	(15.96, -27.76, -97.00)
15:91522512		E>G	B:328	(18.67, -23.98, -87.70)
15:91522498	rs146878209	L>I	B:333	(23.73, -19.22, -93.99)
15:91522492		D>N	B:335	(18.88, -14.56, -92.12)
15:91522489	rs373875570	A>S	B:336	(22.64, -13.30, -93.35)
15:91522482		I>T	B:338	(18.32, -11.26, -96.94)
15:91522483		I>V	B:338	(18.32, -11.26, -96.94)
15:91522476	rs529515389	R>Q	B:340	(23.27, -7.96, -96.08)
15:91522477		R>W	B:340	(23.27, -7.96, -96.08)
15:91522464		Y>C	B:344	(24.79, -3.29, -101.11)
15:91522461		Y>C	B:345	(18.12, -1.50, -101.98)
15:91522427		Q>H	B:356	(15.56, 2.87, -113.37)
15:91522392	COSM3420720	F>S	B:368	(7.86, 10.02, -127.39)
15:91520001		R>G	B:370	(10.17, 6.84, -133.02)
15:91519986		P>T	B:375	(6.48, 9.91, -141.64)
15:91519979		R>Q	B:377	(4.27, 11.71, -138.06)
15:91519967		R>Q	B:381	(-1.51, 9.01, -134.70)
15:91519965		G>R	B:382	(-1.92, 10.47, -131.45)
15:91519959		N>D	B:384	(-1.33, 16.82, -129.51)
15:91519942	rs201488822	E>D	B:389	(7.37, 16.78, -128.81)
15:91519925	rs143841711	L>P	B:395	(12.56, 13.12, -122.07)
15:91519907		K>R	B:401	(21.03, 16.14, -115.88)
15:91517952		E>Q	B:405	(23.90, 13.54, -110.82)
15:91517939	rs531286450	R>Q	B:409	(25.29, 9.52, -106.18)
15:91517936	rs554587791	I>T	B:410	(29.64, 6.19, -109.39)
15:91517919		E>K	B:416	(34.73, 3.36, -101.08)
15:91517906	rs139840373	A>V	B:420	(34.61, -1.27, -110.24)
15:91517891		G>E	B:425	(29.01, -6.19, -118.18)
15:91517892	rs143665955	G>R	B:425	(29.01, -6.19, -118.18)
15:91517883	COSM1221862	F>L	B:428	(28.15, 1.24, -116.79)
15:91517874	rs542771806	Y>D	B:431	(25.07, 0.42, -121.95)
15:91517861		Q>P	B:435	(23.00, 3.12, -126.11)
15:91517862		Q>K	B:435	(23.00, 3.12, -126.11)
15:91517859		W>R	B:436	(23.16, 9.20, -125.45)
15:91517846		R>Q	B:440	(24.31, 9.14, -133.43)
15:91517847	COSM1189106	R>G	B:440	(24.31, 9.14, -133.43)
15:91517837		K>R	B:443	(21.05, 9.87, -137.49)