General Structure Information
| PDB ID | 1lcy |
| HGNC Gene Label(s) | HTRA2 |
| Structure Name | crystal structure of the mitochondrial serine protease htra2 |
| Resolution | 2.0Å |
| Reference | AUTH W.LI,S.M.SRINIVASULA,J.CHAI,P.LI,J.W.WU,Z.ZHANG,E.S.ALNEMRI,AUTH 2 Y.SHITITL STRUCTURAL INSIGHTS INTO THE PRO-APOPTOTIC FUNCTION OFTITL 2 MITOCHONDRIAL SERINE PROTEASE HTRA2/OMI.REF NAT.STRUCT.BIOL. V. 9 436 2002REFN ISSN 1072-8368PMID 11967569DOI 10.1038/NSB795 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 296 |
| Number Of SNVs | 48 |
| Number Of Permutations | 11593 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.084 |
| p-value | 0.3 |
ClinVar
| Number Of Residues | 296 |
| Number Of SNVs | 3 |
| Number Of Permutations | 231 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.333 |
| p-value | 0.338 |
COSMIC
| Number Of Residues | 296 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1594 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.167 |
| p-value | 0.407 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 48 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.309 |
| p-value | 0.293 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 48 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | -0.286 |
| p-value | 0.601 |