General Structure Information
| PDB ID | 1yok |
| HGNC Gene Label(s) | NR5A2 |
| Structure Name | crystal structure of human lrh-1 bound with tif-2 peptide and phosphatidylglycerol |
| Resolution | 2.5Å |
| Reference | AUTH I.N.KRYLOVA,E.P.SABLIN,J.MOORE,R.X.XU,G.M.WAITT,AUTH 2 J.A.MACKAY,D.JUZUMIENE,J.M.BYNUM,K.MADAUSS,AUTH 3 V.MONTANA,L.LEBEDEVA,M.SUZAWA,J.D.WILLIAMS,AUTH 4 S.P.WILLIAMS,R.K.GUY,J.W.THORNTON,R.J.FLETTERICK,AUTH 5 T.M.WILLSON,H.A.INGRAHAMTITL STRUCTURAL ANALYSES REVEAL PHOSPHATIDYL INOSITOLSTITL 2 AS LIGANDS FOR THE NR5 ORPHAN RECEPTORS SF-1 ANDTITL 3 LRH-1.REF CELL(CAMBRIDGE,MASS.) V. 120 343 2005REFN ISSN 0092-8674PMID 15707893DOI 10.1016/J.CELL.2005.01.024 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 236 |
| Number Of SNVs | 44 |
| Number Of Permutations | 23014 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.251 |
| p-value | 0.517 |
COSMIC
| Number Of Residues | 236 |
| Number Of SNVs | 4 |
| Number Of Permutations | 43 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.333 |
| p-value | 0.535 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 44 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.237 |
| p-value | 0.644 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
