General Structure Information
| PDB ID | 1nun |
| HGNC Gene Label(s) | FGF10 |
| Structure Name | crystal structure analysis of the fgf10-fgfr2b complex |
| Resolution | 2.9Å |
| Reference | AUTH B.K.YEH,M.IGARASHI,A.V.ELISEENKOVA,A.N.PLOTNIKOV,AUTH 2 I.SHER,D.RON,S.A.AARONSON,M.MOHAMMADITITL STRUCTURAL BASIS BY WHICH ALTERNATIVE SPLICINGTITL 2 CONFERS SPECIFICITY IN FIBROBLAST GROWTH FACTORTITL 3 RECEPTORS.REF PROC.NATL.ACAD.SCI.USA V. 100 2266 2003REFN ISSN 0027-8424PMID 12591959DOI 10.1073/PNAS.0436500100 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 139 |
| Number Of SNVs | 14 |
| Number Of Permutations | 3853 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.11 |
| p-value | 0.259 |
ClinVar
| Number Of Residues | 139 |
| Number Of SNVs | 4 |
| Number Of Permutations | 423 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.0 |
| p-value | 0.357 |
COSMIC
| Number Of Residues | 139 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 14 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | -0.176 |
| p-value | 0.368 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 14 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | -0.253 |
| p-value | 0.112 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
