General Structure Information
| PDB ID | 2xri |
| HGNC Gene Label(s) | ERI3 |
| Structure Name | crystal structure of human eri1 exoribonuclease 3 |
| Resolution | 2.15Å |
| Reference | AUTH M.WELIN,M.I.SIPONEN,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,H.SCHULER,P.SCHUTZ,AUTH 5 A.G.THORSELL,L.TRESAUGUES,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN ERI1 EXORIBONUCLEASE 3REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 199 |
| Number Of SNVs | 24 |
| Number Of Permutations | 7588 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.105 |
| p-value | 0.055 |
COSMIC
| Number Of Residues | 199 |
| Number Of SNVs | 3 |
| Number Of Permutations | 160 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.333 |
| p-value | 0.924 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 24 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | -0.286 |
| p-value | 0.645 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
