General Structure Information
| PDB ID | 2z5f |
| HGNC Gene Label(s) | SULT1B1 |
| Structure Name | human sulfotransferase sult1b1 in complex with pap |
| Resolution | 2.1Å |
| Reference | AUTH L.DOMBROVSKI,A.DONG,A.BOCHKAREV,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURES OF HUMAN SULFOTRANSFERASESTITL 2 SULT1B1 AND SULT1C1 COMPLEXED WITH THE COFACTORTITL 3 PRODUCT ADENOSINE-3-5-DIPHOSPHATE (PAP)REF PROTEINS V. 64 1091 2006REFN ISSN 0887-3585PMID 16804942DOI 10.1002/PROT.21048 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 293 |
| Number Of SNVs | 99 |
| Number Of Permutations | 9977 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.041 |
| p-value | 0.832 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 4:70620910 | COSM1057014 | R>Q | B:9 | (-0.19, -13.16, 17.53) |
| 4:70620889 | H>R | B:16 | (-11.30, 4.04, 29.06) | |
| 4:70620883 | rs149663789 | Y>F | B:18 | (-8.44, 4.43, 23.53) |
| 4:70620881 | rs139481063 | P>A | B:19 | (-7.88, -0.18, 20.84) |
| 4:70620878 | rs150530193 | M>V | B:20 | (-5.14, -1.79, 24.28) |
| 4:70620874 | rs547319603 | T>N | B:21 | (-2.31, -5.18, 23.77) |
| 4:70620858 | rs143490828 | S>R | B:26 | (-5.24, -6.27, 32.61) |
| 4:70620857 | rs139571740 | N>D | B:27 | (-4.58, -5.32, 36.28) |
| 4:70620852 | W>C | B:28 | (-5.42, 0.34, 32.61) | |
| 4:70620823 | P>Q | B:38 | (8.49, 15.04, 41.43) | |
| 4:70620812 | V>L | B:42 | (7.28, 11.19, 30.74) | |
| 4:70620505 | V>F | B:54 | (14.31, 9.32, 23.12) | |
| 4:70620495 | I>S | B:57 | (19.00, 10.36, 24.00) | |
| 4:70620480 | L>P | B:62 | (19.90, 11.84, 33.19) | |
| 4:70620477 | N>S | B:63 | (23.96, 9.08, 33.33) | |
| 4:70620468 | D>G | B:66 | (28.76, 7.30, 31.72) | |
| 4:70620463 | COSM1694474 | E>K | B:68 | (29.94, 1.65, 31.09) |
| 4:70620460 | K>E | B:69 | (26.59, 5.32, 34.55) | |
| 4:70620450 | rs370321903 | R>Q | B:72 | (22.01, 0.99, 34.22) |
| 4:70620448 | rs201366294 | G>S | B:73 | (20.93, -2.40, 31.61) |
| 4:70620442 | I>V | B:75 | (15.78, -0.42, 27.65) | |
| 4:70620438 | T>I | B:76 | (13.18, -3.18, 29.90) | |
| 4:70620424 | M>V | B:81 | (5.95, 0.12, 28.98) | |
| 4:70620415 | M>L | B:84 | (4.59, -3.89, 30.34) | |
| 4:70620405 | P>L | B:87 | (2.13, -12.10, 33.38) | |
| 4:70620398 | rs570118846 COSM588294 |
L>F | B:89 | (7.50, -14.07, 31.01) |
| 4:70615527 | rs376735076 | Q>R | B:96 | (11.31, -2.37, 37.16) |
| 4:70615509 | rs143204643 | S>L | B:102 | (15.23, 9.00, 41.31) |
| 4:70615507 | rs570066281 | P>S | B:103 | (15.91, 10.47, 38.09) |
| 4:70615503 | rs149557615 | R>Q | B:104 | (10.90, 7.19, 38.41) |
| 4:70615499 | rs151192985 | I>M | B:105 | (13.20, 7.45, 32.50) |
| 4:70615500 | I>T | B:105 | (13.20, 7.45, 32.50) | |
| 4:70615497 | V>A | B:106 | (8.38, 6.88, 32.41) | |
| 4:70615488 | rs57806190 | H>R | B:109 | (3.06, 4.00, 23.75) |
| 4:70615482 | rs150406987 | P>L | B:111 | (-3.68, 8.11, 25.64) |
| 4:70615479 | T>N | B:112 | (-3.83, 12.44, 27.21) | |
| 4:70615475 | D>E | B:113 | (-7.47, 10.12, 28.17) | |
| 4:70615453 | rs369744404 | E>K | B:121 | (-1.47, 15.70, 40.38) |
| 4:70615450 | COSM3605367 | N>D | B:122 | (3.81, 15.68, 40.80) |
| 4:70615446 | N>S | B:123 | (4.64, 19.65, 37.08) | |
| 4:70599981 | rs563357509 | M>T | B:126 | (6.12, 15.17, 29.96) |
| 4:70599969 | A>V | B:130 | (6.36, 12.58, 16.73) | |
| 4:70599970 | A>S | B:130 | (6.36, 12.58, 16.73) | |
| 4:70599966 | rs371978235 COSM1328431 COSM1057011 |
R>H | B:131 | (7.80, 8.33, 12.82) |
| 4:70599958 | K>E | B:134 | (2.70, 8.00, 5.47) | |
| 4:70599954 | D>V | B:135 | (7.12, 6.19, 8.26) | |
| 4:70599955 | rs201965140 | D>N | B:135 | (7.12, 6.19, 8.26) |
| 4:70599952 | rs186114237 | V>I | B:136 | (4.06, 5.03, 12.10) |
| 4:70599925 | rs11569736 | L>V | B:145 | (5.07, -9.34, 11.34) |
| 4:70599919 | N>D | B:147 | (5.02, -8.51, 18.98) | |
| 4:70599898 | G>S | B:154 | (-1.92, -9.17, 7.69) | |
| 4:70599890 | W>C | B:156 | (0.56, -2.22, 4.11) | |
| 4:70599883 | Y>H | B:159 | (-2.00, -2.47, 9.63) | |
| 4:70599876 | rs141370707 | E>G | B:161 | (-8.44, 0.29, 6.33) |
| 4:70599867 | L>S | B:164 | (-6.33, 5.10, 8.13) | |
| 4:70599856 | rs554426974 | V>L | B:168 | (-4.67, -0.03, 16.06) |
| 4:70599222 | rs141546886 | A>D | B:169 | (-3.02, -0.43, 19.48) |
| 4:70599219 | Y>C | B:170 | (-1.81, 2.26, 22.57) | |
| 4:70599211 | W>G | B:173 | (-0.92, 9.87, 14.01) | |
| 4:70599208 | F>L | B:174 | (-5.00, 10.92, 12.79) | |
| 4:70599201 | H>P | B:176 | (-1.74, 9.81, 20.69) | |
| 4:70599192 | N>T | B:179 | (-5.18, 15.26, 22.13) | |
| 4:70599172 | E>K | B:186 | (-2.30, 22.46, 29.73) | |
| 4:70599159 | L>H | B:190 | (9.92, 18.79, 24.68) | |
| 4:70599160 | L>V | B:190 | (9.92, 18.79, 24.68) | |
| 4:70599147 | Y>C | B:194 | (12.05, 9.87, 13.64) | |
| 4:70599137 | rs201499254 | M>I | B:197 | (16.48, 13.58, 16.15) |
| 4:70599135 | K>R | B:198 | (17.33, 10.94, 11.31) | |
| 4:70596395 | COSM1694473 | P>L | B:201 | (20.81, 15.03, 15.79) |
| 4:70596389 | E>G | B:203 | (19.98, 21.71, 17.52) | |
| 4:70596385 | rs4149416 | E>D | B:204 | (16.39, 18.17, 18.30) |
| 4:70596367 | rs560473020 | R>S | B:210 | (18.12, 23.46, 26.21) |
| 4:70596369 | R>G | B:210 | (18.12, 23.46, 26.21) | |
| 4:70596358 | E>D | B:213 | (17.29, 21.60, 34.15) | |
| 4:70596355 | K>N | B:214 | (21.96, 18.26, 32.76) | |
| 4:70596344 | rs542132053 | D>G | B:218 | (30.30, 20.23, 22.42) |
| 4:70596332 | rs181598666 | D>G | B:222 | (29.61, 14.89, 19.70) |
| 4:70596326 | rs562541624 | I>T | B:224 | (24.91, 11.51, 23.17) |
| 4:70596320 | rs529343784 | H>R | B:226 | (28.63, 7.41, 17.91) |
| 4:70596318 | rs374341407 COSM3409441 |
H>N | B:227 | (25.40, 5.47, 22.47) |
| 4:70596314 | rs370350048 | T>N | B:228 | (22.08, 7.52, 19.89) |
| 4:70596303 | V>L | B:232 | (25.44, 2.07, 17.42) | |
| 4:70596293 | rs201116405 | D>G | B:235 | (24.63, -3.52, 16.66) |
| 4:70596287 | P>L | B:237 | (22.73, -5.72, 23.15) | |
| 4:70596285 | rs567371342 | L>V | B:238 | (21.57, -3.39, 26.44) |
| 4:70596275 | Y>C | B:241 | (13.60, -4.33, 22.83) | |
| 4:70596258 | T>A | B:247 | (7.11, -15.78, 23.29) | |
| 4:70596227 | rs375995089 | M>T | B:257 | (16.43, -1.80, 15.58) |
| 4:70596224 | rs142990488 | R>H | B:258 | (12.41, -1.63, 9.83) |
| 4:70596222 | K>Q | B:259 | (14.62, 0.22, 7.41) | |
| 4:70592915 | rs11569729 | T>M | B:261 | (14.50, 5.79, 7.73) |
| 4:70592912 | A>D | B:262 | (12.68, 8.98, 6.67) | |
| 4:70592909 | G>D | B:263 | (10.56, 7.36, 3.77) | |
| 4:70592888 | T>N | B:270 | (0.05, 1.86, -3.22) | |
| 4:70592889 | T>S | B:270 | (0.05, 1.86, -3.22) | |
| 4:70592886 | rs369976377 | V>M | B:271 | (-0.36, 5.51, -5.76) |
| 4:70592882 | A>D | B:272 | (-3.96, 4.28, -4.08) | |
| 4:70592880 | Q>K | B:273 | (-2.42, 2.55, -0.32) | |
| 4:70592864 | D>V | B:278 | (-3.08, 12.12, 1.55) | |
| 4:70592861 | rs376364619 COSM1057007 |
A>V | B:279 | (-7.78, 12.43, 2.29) |
| 4:70592859 | I>V | B:280 | (-8.13, 10.26, 5.64) | |
| 4:70592842 | M>I | B:285 | (-4.23, 16.87, 10.70) | |
| 4:70592840 | S>F | B:286 | (-6.33, 20.87, 8.18) | |
| 4:70592820 | rs143470126 | R>C | B:293 | (9.88, 16.78, 7.63) |
| 4:70592813 | E>G | B:295 | (10.50, 13.28, 2.34) |