General Structure Information
| PDB ID | 4hn2 |
| HGNC Gene Label(s) | PPIP5K2 |
| Structure Name | crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (ppip5k2) in complex with amppnp and a substrate analog 5pa-ip5 |
| Resolution | 1.9Å |
| Reference | AUTH A.M.RILEY,H.WANG,J.D.WEAVER,S.B.SHEARS,B.V.POTTERTITL FIRST SYNTHETIC ANALOGUES OF DIPHOSPHOINOSITOLTITL 2 POLYPHOSPHATES: INTERACTION WITH PP-INSP(5) KINASE.REF CHEM.COMMUN.(CAMB.) V. 48 11292 2012REFN ISSN 1359-7345PMID 23032903DOI 10.1039/C2CC36044F |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 325 |
| Number Of SNVs | 37 |
| Number Of Permutations | 24384 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.146 |
| p-value | 0.808 |
COSMIC
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 37 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | -0.279 |
| p-value | 0.449 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
