General Structure Information
| PDB ID | 3mtt |
| HGNC Gene Label(s) | PIK3R2 |
| Structure Name | crystal structure of ish2 domain of human p85beta, northeast structural genomics consortium target hr5531c |
| Resolution | 3.3Å |
| Reference | AUTH C.SCHAUDER,L.C.MA,R.M.KRUG,G.T.MONTELIONE,R.GUANTITL STRUCTURE OF THE ISH2 DOMAIN OF HUMAN PHOSPHATIDYLINOSITOLTITL 2 3-KINASE P85BETA SUBUNIT REVEALS CONFORMATIONAL PLASTICITYTITL 3 IN THE INTERHELICAL TURN REGIONREF ACTA CRYSTALLOGR.,SECT.F V. 66 1567 2010REFN ESSN 1744-3091PMID 21139197DOI 10.1107/S1744309110041333 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 163 |
| Number Of SNVs | 31 |
| Number Of Permutations | 30350 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.049 |
| p-value | 0.862 |
COSMIC
| Number Of Residues | 163 |
| Number Of SNVs | 4 |
| Number Of Permutations | 358 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.167 |
| p-value | 0.971 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 31 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 51.0 |
| K Statistic | 0.329 |
| p-value | 0.467 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
