General Structure Information
| PDB ID | 4gqb |
| HGNC Gene Label(s) | PRMT5 |
| Structure Name | crystal structure of the human prmt5:mep50 complex |
| Resolution | 2.06Å |
| Reference | AUTH S.ANTONYSAMY,Z.BONDAY,R.M.CAMPBELL,B.DOYLE,Z.DRUZINA,AUTH 2 T.GHEYI,B.HAN,L.N.JUNGHEIM,Y.QIAN,C.RAUCH,M.RUSSELL,AUTH 3 J.M.SAUDER,S.R.WASSERMAN,K.WEICHERT,F.S.WILLARD,A.ZHANG,AUTH 4 S.EMTAGETITL CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 109 17960 2012REFN ISSN 0027-8424PMID 23071334DOI 10.1073/PNAS.1209814109 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 625 |
| Number Of SNVs | 106 |
| Number Of Permutations | 73755 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.077 |
| p-value | 0.989 |
COSMIC
| Number Of Residues | 625 |
| Number Of SNVs | 3 |
| Number Of Permutations | 140 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 106 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 50.0 |
| K Statistic | -0.384 |
| p-value | 0.586 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
