General Structure Information
| PDB ID | 4o0x |
| HGNC Gene Label(s) | PAK4 |
| Structure Name | back pocket flexibility provides group-ii pak selectivity for type 1 kinase inhibitors |
| Resolution | 2.48Å |
| Reference | AUTH S.T.STABEN,J.A.FENG,K.LYLE,M.BELVIN,J.BOGGS,J.D.BURCH,AUTH 2 C.C.CHUA,H.CUI,A.G.DIPASQUALE,L.S.FRIEDMAN,C.HEISE,AUTH 3 H.KOEPPEN,A.KOTEY,R.MINTZER,A.OH,D.A.ROBERTS,L.ROUGE,AUTH 4 J.RUDOLPH,C.TAM,W.WANG,Y.XIAO,A.YOUNG,Y.ZHANG,K.P.HOEFLICHTITL BACK POCKET FLEXIBILITY PROVIDES GROUP II P21-ACTIVATEDTITL 2 KINASE (PAK) SELECTIVITY FOR TYPE I 1/2 KINASE INHIBITORS.REF J.MED.CHEM. V. 57 1033 2014REFN ISSN 0022-2623PMID 24432870DOI 10.1021/JM401768T |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 289 |
| Number Of SNVs | 78 |
| Number Of Permutations | 9787 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.022 |
| p-value | 0.935 |