General Structure Information
| PDB ID | 4l6q |
| HGNC Gene Label(s) | ROCK2 |
| Structure Name | rock2 in complex with benzoxaborole |
| Resolution | 2.79Å |
| Reference | AUTH T.AKAMA,C.DONG,C.VIRTUCIO,D.SULLIVAN,Y.ZHOU,Y.K.ZHANG,AUTH 2 F.ROCK,Y.FREUND,L.LIU,W.BU,A.WU,X.Q.FAN,K.JARNAGINTITL LINKING PHENOTYPE TO KINASE: IDENTIFICATION OF A NOVELTITL 2 BENZOXABOROLE HINGE-BINDING MOTIF FOR KINASE INHIBITION ANDTITL 3 DEVELOPMENT OF HIGH-POTENCY RHO KINASE INHIBITORS.REF J.PHARMACOL.EXP.THER. V. 347 615 2013REFN ISSN 0022-3565PMID 24049062DOI 10.1124/JPET.113.207662 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 388 |
| Number Of SNVs | 48 |
| Number Of Permutations | 33838 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.238 |
| p-value | 0.002 |
COSMIC
| Number Of Residues | 388 |
| Number Of SNVs | 6 |
| Number Of Permutations | 5454 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.4 |
| p-value | 0.704 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 48 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.116 |
| p-value | 0.856 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
