General Structure Information
| PDB ID | 4kc3 |
| HGNC Gene Label(s) | IL1RL1 |
| Structure Name | cytokine/receptor binary complex |
| Resolution | 3.27Å |
| Reference | AUTH X.LIU,M.HAMMEL,Y.HE,J.A.TAINER,U.S.JENG,L.ZHANG,S.WANG,AUTH 2 X.WANGTITL STRUCTURAL INSIGHTS INTO THE INTERACTION OF IL-33 WITH ITSTITL 2 RECEPTORS.REF PROC.NATL.ACAD.SCI.USA V. 110 14918 2013REFN ISSN 0027-8424PMID 23980170DOI 10.1073/PNAS.1308651110 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 278 |
| Number Of SNVs | 83 |
| Number Of Permutations | 50497 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.016 |
| p-value | 0.877 |
COSMIC
| Number Of Residues | 278 |
| Number Of SNVs | 11 |
| Number Of Permutations | 5283 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.091 |
| p-value | 0.692 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 83 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 38.0 |
| K Statistic | 0.264 |
| p-value | 0.224 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
