General Structure Information
| PDB ID | 4dkd |
| HGNC Gene Label(s) | CSF1R |
| Structure Name | crystal structure of human interleukin-34 bound to human csf-1r |
| Resolution | 3.0Å |
| Reference | AUTH X.MA,W.Y.LIN,Y.CHEN,S.STAWICKI,K.MUKHYALA,Y.WU,F.MARTIN,AUTH 2 J.F.BAZAN,M.A.STAROVASNIKTITL STRUCTURAL BASIS FOR THE DUAL RECOGNITION OF HELICALTITL 2 CYTOKINES IL-34 AND CSF-1 BY CSF-1R.REF STRUCTURE V. 20 676 2012REFN ISSN 0969-2126PMID 22483114DOI 10.1016/J.STR.2012.02.010 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 272 |
| Number Of SNVs | 82 |
| Number Of Permutations | 24270 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.176 |
| p-value | 0.025 |
COSMIC
| Number Of Residues | 272 |
| Number Of SNVs | 7 |
| Number Of Permutations | 2697 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.048 |
| p-value | 0.644 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 82 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.065 |
| p-value | 0.48 |