General Structure Information
| PDB ID | 4af3 |
| HGNC Gene Label(s) | AURKB |
| Structure Name | human aurora b kinase in complex with incenp and vx-680 |
| Resolution | 2.75Å |
| Reference | AUTH J.M.ELKINS,S.SANTAGUIDA,A.MUSACCHIO,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN AURORA B IN COMPLEX WITH INCENPTITL 2 AND VX-680.REF J.MED.CHEM. V. 55 7841 2012REFN ISSN 0022-2623PMID 22920039DOI 10.1021/JM3008954 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 253 |
| Number Of SNVs | 60 |
| Number Of Permutations | 8022 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.029 |
| p-value | 0.21 |
COSMIC
| Number Of Residues | 253 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1346 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.133 |
| p-value | 0.783 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 60 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | -0.354 |
| p-value | 0.214 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
