General Structure Information
| PDB ID | 3vn4 |
| HGNC Gene Label(s) | ADAMTS13 |
| Structure Name | crystal structure of the exosite-containing fragment of human adamts13 (p475s mutant) |
| Resolution | 2.8Å |
| Reference | AUTH D.NAKAYAMA,M.AKIYAMA,S.TAKEDA,K.KOKAME,J.TAKAGI,T.MIYATATITL STRUCTURAL ANALYSIS AND BIOCHEMICAL STUDIES OF ADAMTS13TITL 2 P475S MUTANTREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 375 |
| Number Of SNVs | 105 |
| Number Of Permutations | 35602 |
| Optimal Distance Threshold | 33.0 |
| K Statistic | 0.526 |
| p-value | 0.041 |
ClinVar
| Number Of Residues | 375 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1674 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 1.0 |
| p-value | 0.006 |
COSMIC
| Number Of Residues | 375 |
| Number Of SNVs | 4 |
| Number Of Permutations | 269 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.5 |
| p-value | 0.572 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 105 |
| Number Of ClinVar SNVs | 5 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.709 |
| p-value | 0.016 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 105 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 35.0 |
| K Statistic | 0.433 |
| p-value | 0.78 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
