General Structure Information
| PDB ID | 3p53 |
| HGNC Gene Label(s) | FSCN1 |
| Structure Name | structure of fascin |
| Resolution | 2.0Å |
| Reference | AUTH S.JANSEN,A.COLLINS,C.YANG,G.REBOWSKI,T.SVITKINA,R.DOMINGUEZTITL MECHANISM OF ACTIN FILAMENT BUNDLING BY FASCIN.REF J.BIOL.CHEM. V. 286 30087 2011REFN ISSN 0021-9258PMID 21685497DOI 10.1074/JBC.M111.251439 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 484 |
| Number Of SNVs | 102 |
| Number Of Permutations | 52698 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.17 |
| p-value | 0.03 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 7:5632586 | A>T | B:7 | (75.48, -53.24, 8.18) | |
| 7:5632592 | A>T | B:9 | (70.61, -49.24, 6.57) | |
| 7:5632622 | C>G | B:19 | (51.60, -23.95, 6.61) | |
| 7:5632623 | C>Y | B:19 | (51.60, -23.95, 6.61) | |
| 7:5632629 | N>S | B:21 | (48.56, -28.40, 9.46) | |
| 7:5632662 | K>T | B:32 | (49.16, -33.32, -9.49) | |
| 7:5632712 | E>K | B:49 | (66.91, -42.38, -2.19) | |
| 7:5632733 | G>R | B:56 | (79.77, -34.98, -2.24) | |
| 7:5632745 | V>L | B:60 | (68.50, -35.59, -0.12) | |
| 7:5632775 | L>V | B:70 | (60.53, -34.17, -5.45) | |
| 7:5632779 | rs201797140 | A>E | B:71 | (61.59, -31.96, -8.65) |
| 7:5632790 | D>N | B:75 | (61.93, -21.78, -13.56) | |
| 7:5632816 | E>D | B:83 | (61.61, -43.02, -13.80) | |
| 7:5632818 | V>G | B:84 | (66.21, -41.29, -12.61) | |
| 7:5632823 | G>R | B:86 | (68.84, -35.50, -10.51) | |
| 7:5632824 | G>D | B:86 | (68.84, -35.50, -10.51) | |
| 7:5632826 | P>A | B:87 | (70.34, -32.50, -11.01) | |
| 7:5632853 | H>Y | B:96 | (64.80, -24.48, 11.05) | |
| 7:5632861 | rs146600697 | D>E | B:98 | (60.69, -24.62, 14.77) |
| 7:5632866 | R>L | B:100 | (58.66, -25.86, 11.24) | |
| 7:5632868 | W>R | B:101 | (62.85, -30.97, 7.91) | |
| 7:5632887 | COSM601852 | A>E | B:107 | (70.99, -26.33, -7.99) |
| 7:5632891 | H>Q | B:108 | (68.28, -24.46, -8.93) | |
| 7:5632919 | rs530561276 | R>C | B:118 | (48.21, -23.18, -4.71) |
| 7:5632922 | L>M | B:119 | (53.32, -26.61, -4.04) | |
| 7:5632925 | S>T | B:120 | (56.89, -23.71, -5.36) | |
| 7:5632949 | P>A | B:128 | (56.14, -19.40, 7.01) | |
| 7:5632979 | M>V | B:138 | (60.91, -45.05, 9.80) | |
| 7:5633025 | A>G | B:153 | (75.58, -45.93, 20.92) | |
| 7:5633033 | S>G | B:156 | (76.62, -46.03, 30.30) | |
| 7:5633045 | A>T | B:160 | (75.64, -43.51, 34.61) | |
| 7:5633048 | D>N | B:161 | (72.87, -41.31, 34.11) | |
| 7:5633070 | D>V | B:168 | (83.59, -51.79, 18.85) | |
| 7:5633129 | rs371640415 | V>M | B:188 | (67.10, -39.97, 22.05) |
| 7:5633130 | V>E | B:188 | (67.10, -39.97, 22.05) | |
| 7:5633141 | D>N | B:192 | (66.19, -46.95, 30.40) | |
| 7:5633148 | R>H | B:194 | (66.78, -42.91, 31.12) | |
| 7:5633222 | G>S | B:219 | (73.76, -40.95, 4.80) | |
| 7:5633253 | R>H | B:229 | (73.28, -26.41, 20.97) | |
| 7:5633268 | S>L | B:234 | (82.42, -35.81, 24.37) | |
| 7:5633277 | COSM3995654 | S>N | B:237 | (83.35, -42.00, 26.33) |
| 7:5633278 | S>R | B:237 | (83.35, -42.00, 26.33) | |
| 7:5633294 | G>C | B:243 | (78.06, -28.93, 20.96) | |
| 7:5633304 | T>S | B:246 | (75.68, -23.86, 14.80) | |
| 7:5633309 | V>M | B:248 | (76.57, -30.05, 10.27) | |
| 7:5633310 | V>A | B:248 | (76.57, -30.05, 10.27) | |
| 7:5633324 | L>F | B:253 | (77.52, -36.84, 10.88) | |
| 7:5633338 | E>D | B:257 | (72.97, -49.15, 11.59) | |
| 7:5642923 | rs201645418 | D>N | B:290 | (77.75, -59.31, 25.66) |
| 7:5642950 | rs373803657 | D>N | B:299 | (68.14, -66.12, 4.94) |
| 7:5642954 | R>H | B:300 | (66.59, -61.12, 3.21) | |
| 7:5642963 | K>R | B:303 | (63.29, -68.00, 5.80) | |
| 7:5642966 | K>M | B:304 | (67.71, -72.07, 7.18) | |
| 7:5642967 | K>N | B:304 | (67.71, -72.07, 7.18) | |
| 7:5642977 | R>C | B:308 | (77.59, -62.37, 14.08) | |
| 7:5642978 | R>H | B:308 | (77.59, -62.37, 14.08) | |
| 7:5642987 | rs111761155 | T>M | B:311 | (83.90, -61.80, 18.07) |
| 7:5642994 | K>N | B:313 | (83.47, -65.86, 14.88) | |
| 7:5643002 | rs143738037 | T>M | B:316 | (80.09, -73.53, 13.38) |
| 7:5643008 | rs150576558 | T>M | B:318 | (82.22, -79.34, 13.64) |
| 7:5643020 | G>D | B:322 | (80.05, -79.75, 16.87) | |
| 7:5643022 | COSM123262 | V>M | B:323 | (78.52, -76.30, 18.05) |
| 7:5643038 | S>F | B:328 | (84.18, -65.41, 10.15) | |
| 7:5643152 | E>K | B:339 | (61.07, -77.25, 15.01) | |
| 7:5643159 | rs377275041 COSM3881920 |
R>H | B:341 | (58.56, -77.72, 19.38) |
| 7:5643164 | R>W | B:343 | (56.03, -71.63, 26.57) | |
| 7:5643165 | R>Q | B:343 | (56.03, -71.63, 26.57) | |
| 7:5643167 | rs186765948 | R>C | B:344 | (60.69, -74.23, 25.32) |
| 7:5643168 | COSM1090973 | R>H | B:344 | (60.69, -74.23, 25.32) |
| 7:5643183 | A>V | B:349 | (71.90, -78.99, 11.67) | |
| 7:5643186 | S>Y | B:350 | (73.85, -79.15, 8.14) | |
| 7:5643189 | N>S | B:351 | (73.90, -82.94, 10.44) | |
| 7:5643197 | F>I | B:354 | (67.48, -82.35, 15.94) | |
| 7:5643234 | S>L | B:366 | (73.86, -85.92, 18.05) | |
| 7:5643236 | V>M | B:367 | (69.74, -85.87, 18.11) | |
| 7:5643246 | A>V | B:370 | (63.46, -84.64, 19.28) | |
| 7:5643518 | K>R | B:379 | (65.36, -64.16, 26.52) | |
| 7:5643530 | R>H | B:383 | (63.71, -54.85, 20.63) | |
| 7:5643541 | COSM1637149 | V>M | B:387 | (57.76, -50.82, 17.47) |
| 7:5643547 | rs369724252 | R>C | B:389 | (56.35, -50.66, 9.45) |
| 7:5643548 | R>H | B:389 | (56.35, -50.66, 9.45) | |
| 7:5643574 | COSM1451653 | R>C | B:398 | (41.18, -47.75, 18.37) |
| 7:5643575 | R>H | B:398 | (41.18, -47.75, 18.37) | |
| 7:5643580 | V>I | B:400 | (38.70, -44.51, 22.38) | |
| 7:5643581 | V>D | B:400 | (38.70, -44.51, 22.38) | |
| 7:5643584 | rs139232758 | T>M | B:401 | (38.35, -48.62, 22.62) |
| 7:5643587 | G>D | B:402 | (41.74, -50.44, 23.42) | |
| 7:5643604 | R>C | B:408 | (47.38, -46.18, 14.52) | |
| 7:5643605 | COSM325372 | R>H | B:408 | (47.38, -46.18, 14.52) |
| 7:5643619 | rs146612530 | V>I | B:413 | (56.23, -47.55, 22.42) |
| 7:5643638 | rs546804171 | N>S | B:419 | (56.54, -66.11, 30.65) |
| 7:5643646 | rs202027851 | A>T | B:422 | (56.45, -66.21, 26.35) |
| 7:5643649 | Y>H | B:423 | (57.73, -62.95, 24.45) | |
| 7:5643653 | N>S | B:424 | (53.80, -60.77, 28.33) | |
| 7:5644924 | T>M | B:434 | (44.17, -59.49, 26.13) | |
| 7:5644933 | S>N | B:437 | (35.53, -63.68, 22.09) | |
| 7:5644941 | rs371109603 | A>T | B:440 | (40.43, -59.10, 19.45) |
| 7:5644942 | rs17850070 | A>V | B:440 | (40.43, -59.10, 19.45) |
| 7:5644944 | V>I | B:441 | (44.10, -57.72, 20.37) | |
| 7:5644956 | G>S | B:445 | (44.48, -55.81, 30.75) | |
| 7:5644959 | rs140594742 | D>N | B:446 | (44.33, -56.33, 34.46) |
| 7:5644965 | rs371278589 | P>A | B:448 | (48.80, -61.22, 31.03) |
| 7:5644973 | D>E | B:450 | (51.24, -65.95, 27.34) | |
| 7:5644983 | E>Q | B:454 | (57.05, -67.64, 15.12) | |
| 7:5644993 | D>G | B:457 | (62.23, -62.20, 7.67) | |
| 7:5645016 | V>M | B:465 | (47.57, -66.65, 20.35) | |
| 7:5645017 | V>A | B:465 | (47.57, -66.65, 20.35) | |
| 7:5645022 | rs199567587 | G>R | B:467 | (47.24, -70.94, 17.01) |
| 7:5645026 | rs373729143 | R>H | B:468 | (44.39, -69.22, 15.06) |
| 7:5645036 | rs368024232 | K>N | B:471 | (45.95, -60.71, 10.33) |
| 7:5645040 | D>N | B:473 | (41.00, -56.82, 9.81) | |
| 7:5645041 | rs150409871 | D>G | B:473 | (41.00, -56.82, 9.81) |
| 7:5645052 | rs566496938 | V>I | B:477 | (41.25, -54.86, 13.54) |
| 7:5645068 | rs142450075 | A>V | B:482 | (45.93, -66.40, 11.21) |
| 7:5645074 | rs570380374 | T>N | B:484 | (49.06, -69.00, 7.80) |
| 7:5645076 | V>M | B:485 | (52.75, -66.70, 7.99) | |
| 7:5645085 | rs369926891 COSM1451657 |
A>T | B:488 | (49.48, -59.60, 7.18) |
| 7:5645091 | L>F | B:490 | (54.96, -60.72, 8.93) |