General Structure Information
| PDB ID | 3n50 |
| HGNC Gene Label(s) | EBF3 |
| Structure Name | human early b-cell factor 3 (ebf3) ipt/tig and hlhlh domains |
| Resolution | 3.1Å |
| Reference | AUTH M.I.SIPONEN,M.WISNIEWSKA,L.LEHTIO,I.JOHANSSON,L.SVENSSON,AUTH 2 G.RASZEWSKI,L.NILSSON,M.SIGVARDSSON,H.BERGLUNDTITL STRUCTURAL DETERMINATION OF FUNCTIONAL DOMAINS IN EARLYTITL 2 B-CELL FACTOR (EBF) FAMILY OF TRANSCRIPTION FACTORS REVEALSTITL 3 SIMILARITIES TO REL DNA-BINDING PROTEINS AND A NOVELTITL 4 DIMERIZATION MOTIF.REF J.BIOL.CHEM. V. 285 25875 2010REFN ISSN 0021-9258PMID 20592035DOI 10.1074/JBC.C110.150482 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 154 |
| Number Of SNVs | 22 |
| Number Of Permutations | 12657 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.013 |
| p-value | 0.523 |
COSMIC
| Number Of Residues | 154 |
| Number Of SNVs | 3 |
| Number Of Permutations | 222 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.333 |
| p-value | 0.34 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 22 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.329 |
| p-value | 0.461 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
