General Structure Information
| PDB ID | 3iuy |
| HGNC Gene Label(s) | DDX53 |
| Structure Name | crystal structure of ddx53 dead-box domain |
| Resolution | 2.4Å |
| Reference | AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASES.REF PLOS ONE V. 5 12791 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 212 |
| Number Of SNVs | 43 |
| Number Of Permutations | 4195 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.003 |
| p-value | 0.176 |
COSMIC
| Number Of Residues | 212 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1751 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.067 |
| p-value | 0.984 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 43 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.051 |
| p-value | 0.957 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
