General Structure Information
| PDB ID | 3exh |
| HGNC Gene Label(s) | PDHB |
| Structure Name | crystal structure of the pyruvate dehydrogenase (e1p) component of human pyruvate dehydrogenase complex |
| Resolution | 2.44Å |
| Reference | AUTH M.KATO,R.M.WYNN,J.L.CHUANG,S.C.TSO,M.MACHIUS,J.LI,D.T.CHUANGTITL STRUCTURAL BASIS FOR INACTIVATION OF THE HUMAN PYRUVATETITL 2 DEHYDROGENASE COMPLEX BY PHOSPHORYLATION: ROLE OF DISORDEREDTITL 3 PHOSPHORYLATION LOOPS.REF STRUCTURE V. 16 1849 2008REFN ISSN 0969-2126PMID 19081061DOI 10.1016/J.STR.2008.10.010 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 329 |
| Number Of SNVs | 61 |
| Number Of Permutations | 28499 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.245 |
| p-value | 0.171 |
COSMIC
| Number Of Residues | 329 |
| Number Of SNVs | 3 |
| Number Of Permutations | 204 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 61 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.207 |
| p-value | 1.0 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
