General Structure Information
| PDB ID | 3c6k |
| HGNC Gene Label(s) | SMS |
| Structure Name | crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine |
| Resolution | 1.95Å |
| Reference | AUTH H.WU,J.MIN,H.ZENG,D.E.MCCLOSKEY,Y.IKEGUCHI,AUTH 2 P.LOPPNAU,A.J.MICHAEL,A.E.PEGG,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURE OF HUMAN SPERMINE SYNTHASE:TITL 2 IMPLICATIONS OF SUBSTRATE BINDING AND CATALYTICTITL 3 MECHANISM.REF J.BIOL.CHEM. V. 283 16135 2008REFN ISSN 0021-9258PMID 18367445DOI 10.1074/JBC.M710323200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 346 |
| Number Of SNVs | 34 |
| Number Of Permutations | 28415 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.271 |
| p-value | 0.035 |
ClinVar
| Number Of Residues | 346 |
| Number Of SNVs | 7 |
| Number Of Permutations | 4583 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.095 |
| p-value | 0.712 |
Ripley’s K Analysis Plots
ExACClinVar
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 34 |
| Number Of ClinVar SNVs | 7 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.079 |
| p-value | 0.922 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
