General Structure Information
| PDB ID | 3ap1 |
| HGNC Gene Label(s) | TPST2 |
| Structure Name | crystal structure of human tyrosylprotein sulfotransferase-2 complexed with pap and c4 peptide |
| Resolution | 1.9Å |
| Reference | AUTH T.TERAMOTO,Y.FUJIKAWA,Y.KAWAGUCHI,K.KUROGI,M.SOEJIMA,AUTH 2 R.ADACHI,Y.NAKANISHI,E.MISHIRO-SATO,M.C.LIU,Y.SAKAKIBARA,AUTH 3 M.SUIKO,M.KIMURA,Y.KAKUTATITL CRYSTAL STRUCTURE OF HUMAN TYROSYLPROTEIN SULFOTRANSFERASE-2TITL 2 REVEALS THE MECHANISM OF PROTEIN TYROSINE SULFATIONTITL 3 REACTION.REF NAT COMMUN V. 4 1572 2013REFN ESSN 2041-1723PMID 23481380DOI 10.1038/NCOMMS2593 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 297 |
| Number Of SNVs | 75 |
| Number Of Permutations | 36924 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.05 |
| p-value | 0.166 |
COSMIC
| Number Of Residues | 297 |
| Number Of SNVs | 6 |
| Number Of Permutations | 213 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.2 |
| p-value | 0.315 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 75 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.405 |
| p-value | 0.201 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
