General Structure Information
| PDB ID | 2p8e |
| HGNC Gene Label(s) | PPM1B |
| Structure Name | crystal structure of the serine/threonine phosphatase domain of human ppm1b |
| Resolution | 1.82Å |
| Reference | AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,AUTH 2 T.P.DILORENZO,V.MALASHKEVICH,S.R.WASSERMAN,AUTH 3 S.SWAMINATHAN,S.ESWARAMOORTHY,R.AGARWAL,D.KUMARAN,AUTH 4 M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,J.ALVARADO,AUTH 5 U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 6 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 280 |
| Number Of SNVs | 56 |
| Number Of Permutations | 8144 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.171 |
| p-value | 0.687 |
COSMIC
| Number Of Residues | 280 |
| Number Of SNVs | 5 |
| Number Of Permutations | 540 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.4 |
| p-value | 0.226 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 56 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.138 |
| p-value | 0.716 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
