General Structure Information
| PDB ID | 2fun |
| HGNC Gene Label(s) | CASP8 |
| Structure Name | alternative p35-caspase-8 complex |
| Resolution | 3.0Å |
| Reference | AUTH M.LU,T.MIN,D.ELIEZER,H.WUTITL NATIVE CHEMICAL LIGATION IN COVALENT CASPASETITL 2 INHIBITION BY P35.REF CHEM.BIOL. V. 13 117 2006REFN ISSN 1074-5521PMID 16492559DOI 10.1016/J.CHEMBIOL.2005.12.007 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 241 |
| Number Of SNVs | 44 |
| Number Of Permutations | 6849 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.153 |
| p-value | 0.499 |
COSMIC
| Number Of Residues | 241 |
| Number Of SNVs | 8 |
| Number Of Permutations | 769 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.143 |
| p-value | 0.073 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 44 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.075 |
| p-value | 0.287 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
